2-(4-((2S)-4-((5-amino-2-thiophenyl)sulfonyl)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Chemical Name:2-(4-((2S)-4-((5-amino-2-thiophenyl)sulfonyl)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol
CAS No.:1361223-67-7
Molecular Formula:C₂₃H₂₈F₆N₄O₄S₂
Molecular Weight:602.622
Hs Code.:

Synonyms:2-(4-((2S)-4-((5-amino-2-thiophenyl)sulfonyl)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Chemical Property of 2-(4-((2S)-4-((5-amino-2-thiophenyl)sulfonyl)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Technology Process of 2-(4-((2S)-4-((5-amino-2-thiophenyl)sulfonyl)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

There total 7 articles about 2-(4-((2S)-4-((5-amino-2-thiophenyl)sulfonyl)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361223-70-2
2-(4-((2S)-4-((5-nitro-2-thiophenyl)sulfonyl)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 1361223-67-7
2-(4-((2S)-4-((5-amino-2-thiophenyl)sulfonyl)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: 2-(4-((2S)-4-((5-nitro-2-thiophenyl)sulfonyl)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol; With iron; acetic acid; at 50 ℃; for 0.666667h;

With sodium hydrogencarbonate; In water;

Reference yield:

: (3S)-3-methyl-4-((2R)-2-piperazinylmethyl)morpholine trihydrochloride

: 1361223-67-7
2-(4-((2S)-4-((5-amino-2-thiophenyl)sulfonyl)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.33 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 12 h / 100 °C / sealed vial

3: acetic acid; iron / 0.67 h / 50 °C

With iron; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

: 350595-57-2
(S)-3-methylmorpholine

: 1361223-67-7
2-(4-((2S)-4-((5-amino-2-thiophenyl)sulfonyl)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: borane-THF / tetrahydrofuran / 16 h / 50 °C

2.2: 20 °C

3.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 6 h / 70 °C

4.1: triethylamine / dichloromethane / 0.33 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 12 h / 100 °C / sealed vial

6.1: acetic acid; iron / 0.67 h / 50 °C

With hydrogenchloride; borane-THF; iron; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;