N2-ISOBUTYRYL-5 , O-(4,4 -DIMETHOXYTRITYL)-2 -O-(2

Base Information

Chemical Name:N2-ISOBUTYRYL-5 , O-(4,4 -DIMETHOXYTRITYL)-2 -O-(2
CAS No.:251647-50-4
Molecular Formula:C38H43 N5 O9
Molecular Weight:713.788
Hs Code.:
Mol file:251647-50-4.mol

Synonyms:19: PN:US20030211606 PAGE: 20 claimed sequence; 20: PN: US20040005569 PAGE: 22 claimedsequence; 22: PN: US20040006030 PAGE: 23 claimed sequence; 22: PN:US20040014047 PAGE: 21 claimed sequence; 22: PN: US20040014049 PAGE: 21 claimedsequence; 23: PN: US20030198965 PAGE: 20 claimed sequence; 23: PN: US20040005570PAGE: 21 claimed sequence; 23: PN: US20040014048 PAGE: 21 claimed sequence; 23:PN: US20040014050 PAGE: 21 claimed sequence; 24: PN: US20040005565 PAGE: 17-22claimed sequence; 24: PN: US20040014051 PAGE: 23 claimed sequence; 25: PN:US20040014699 PAGE: 21 claimed sequence; 26: PN: US20040006029 PAGE: 23 claimedsequence; 26: PN: WO03106645 PAGE: 74 claimed sequence; 97: PN: US20040005707PAGE: 21 claimed sequence

Suppliers and Price of N2-ISOBUTYRYL-5 , O-(4,4 -DIMETHOXYTRITYL)-2 -O-(2

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5''-O-[Bis(4-methoxyphenyl)phenylmethyl]-2''-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)guanosine
5mg
$ 165.00

Crysdot
N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide 97%
100mg
$ 550.00

Crysdot
N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide 97%
250mg
$ 880.00

Chemenu
N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide 97%
250mg
$ 823.00

Biosynth Carbosynth
5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
100 mg
$ 100.00

Biosynth Carbosynth
5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
50 mg
$ 60.00

Biosynth Carbosynth
5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
500 mg
$ 250.00

Biosynth Carbosynth
5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
250 mg
$ 200.00

Biosynth Carbosynth
5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
1 g
$ 460.00

Alichem
N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
250mg
$ 897.60

Total 17 raw suppliers

Chemical Property of N2-ISOBUTYRYL-5 , O-(4,4 -DIMETHOXYTRITYL)-2 -O-(2

Chemical Property:

Melting Point:112.5-126.6 °C(Solv: hexane (110-54-3))
PKA:9.16±0.20(Predicted)
PSA：168.28000
Density:1.33±0.1 g/cm3(Predicted)
LogP:4.10290

Purity/Quality:

99%, ^*data from raw suppliers

5''-O-[Bis(4-methoxyphenyl)phenylmethyl]-2''-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)guanosine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)guanosine is an oligonucleotide analogue which is being researched for the treatment of a wide variety of diseases, cancers, and conditions.

Technology Process of N2-ISOBUTYRYL-5 , O-(4,4 -DIMETHOXYTRITYL)-2 -O-(2

There total 10 articles about N2-ISOBUTYRYL-5 , O-(4,4 -DIMETHOXYTRITYL)-2 -O-(2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 440327-50-4
N²-isobutyryl-2'-O-(2-methoxyethyl)guanosine

: 251647-50-4
5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-N²-isobutyrylguanosine

Guidance literature:: With 2,6-dimethylpyridine; In acetonitrile; for 3h;
DOI:10.1080/15257770802271748

Reference yield: 40.0%

: 40615-35-8
4,4'-dimethoxytrityl alcohol

: 440327-50-4
N²-isobutyryl-2'-O-(2-methoxyethyl)guanosine

: 251647-50-4
5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-N²-isobutyrylguanosine

Guidance literature:: With copper(II) nitrate; In dichloromethane; for 6h; regioselective reaction; Reflux;
DOI:10.1080/15257770.2018.1460480

Reference yield:

: 2096-10-8
adenosine-2-amine

: 251647-50-4
5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-N²-isobutyrylguanosine

Guidance literature:: Multi-step reaction with 6 steps

1: 40 percent / KOH / dimethylsulfoxide / 7 h / 20 °C

2: adenosine deaminase; sodium phosphate buffer / pH 7.2

3: acetonitrile / 3 h / 20 °C

4: 3 h / 20 °C

5: ammonia / acetonitrile; H₂O; acetone / pH 6.4

6: 85 percent / 2,6-lutidine / acetonitrile / 3 h / 45 °C

With 2,6-dimethylpyridine; potassium hydroxide; sodium phosphate buffer; ammonia; adenosine deaminase; In water; dimethyl sulfoxide; acetone; acetonitrile;
DOI:10.1081/NCN-120022957