(R)-3-bromo-N-(2,4-dimethoxybenzyl)-1-(1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Base Information

Chemical Name:(R)-3-bromo-N-(2,4-dimethoxybenzyl)-1-(1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS No.:1620564-51-3
Molecular Formula:C₂₂H₂₄BrN₇O₂
Molecular Weight:498.382
Hs Code.:

Synonyms:(R)-3-bromo-N-(2,4-dimethoxybenzyl)-1-(1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Chemical Property of (R)-3-bromo-N-(2,4-dimethoxybenzyl)-1-(1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Technology Process of (R)-3-bromo-N-(2,4-dimethoxybenzyl)-1-(1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

There total 11 articles about (R)-3-bromo-N-(2,4-dimethoxybenzyl)-1-(1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620564-50-2
(R)-3-bromo-N-(2,4-dimethoxybenzyl)-1-(4,5,6,7-tetrahydro-1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 74-88-4
methyl iodide

: 1620564-51-3
(R)-3-bromo-N-(2,4-dimethoxybenzyl)-1-(1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 1620564-52-4
(R)-3-bromo-N-(2,4-dimethoxybenzyl)-1-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 85302-07-4
2-(dimethylaminomethylene)cyclohexane-1,3-dione

: 1620564-51-3
(R)-3-bromo-N-(2,4-dimethoxybenzyl)-1-(1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 1620564-52-4
(R)-3-bromo-N-(2,4-dimethoxybenzyl)-1-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid / ethanol / 4 h / 70 °C

2: sodium tetrahydroborate; ethanol / tetrahydrofuran / 1 h / Cooling with ice

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4.08 h / 0 - 20 °C / Inert atmosphere

4: chiralpak AS-H 150*4.6mm I_.D_., 5um / methanol / Resolution of racemate

5: lithium hydroxide monohydrate / tetrahydrofuran / 8 h / 60 °C

6: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 70 °C / Microwave irradiation

With sodium tetrahydroborate; lithium hydroxide monohydrate; ethanol; di-isopropyl azodicarboxylate; caesium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 504-02-9
1,3-cylohexanedione

: 1620564-51-3
(R)-3-bromo-N-(2,4-dimethoxybenzyl)-1-(1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 1620564-52-4
(R)-3-bromo-N-(2,4-dimethoxybenzyl)-1-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 7 steps

1: 1 h / 100 °C / Inert atmosphere

2: acetic acid / ethanol / 4 h / 70 °C

3: sodium tetrahydroborate; ethanol / tetrahydrofuran / 1 h / Cooling with ice

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4.08 h / 0 - 20 °C / Inert atmosphere

5: chiralpak AS-H 150*4.6mm I_.D_., 5um / methanol / Resolution of racemate

6: lithium hydroxide monohydrate / tetrahydrofuran / 8 h / 60 °C

7: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 70 °C / Microwave irradiation

With sodium tetrahydroborate; lithium hydroxide monohydrate; ethanol; di-isopropyl azodicarboxylate; caesium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;