2-chloro-N-(4-methoxy-2-nitrophenyl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(4-methoxy-2-nitrophenyl)acetamide
• CAS No.: 3223-77-6
• Molecular Formula: C9H9 Cl N2 O4
• Molecular Weight: 244.634
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID50394522
• Nikkaji Number: J2.795.546K
• Wikidata: Q82193964
• Mol file: 3223-77-6.mol

Synonyms:2-chloro-N-(4-methoxy-2-nitrophenyl)acetamide;3223-77-6;2-Chloro-N-(4-methoxy-2-nitro-phenyl)-acetamide;MFCD00157386;DTXSID50394522;STK297814;AKOS000295679;CS-0307513;EN300-01575;N-(2-Nitro-4-methoxyphenyl)-2-chloroacetamide;2-CHLORO-4'-METHOXY-2'-NITROACETANILIDE;SR-01000031032;SR-01000031032-1;Z56813050

Chemical Property of 2-chloro-N-(4-methoxy-2-nitrophenyl)acetamide

Chemical Property:

• Melting Point: 101 °C(Solv: ethanol (64-17-5))
• Boiling Point: 463.1±45.0 °C(Predicted)
• PKA: 11.01±0.70(Predicted)
• PSA: 84.15000
• Density: 1.441±0.06 g/cm3(Predicted)
• LogP: 2.37690
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 244.0250845
• Heavy Atom Count: 16
• Complexity: 269

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-N-(4-methoxy-2-nitro-phenyl)-acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)NC(=O)CCl)[N+](=O)[O-]

Technology Process of 2-chloro-N-(4-methoxy-2-nitrophenyl)acetamide

There total 6 articles about 2-chloro-N-(4-methoxy-2-nitrophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloroacetyl chloride (79-04-9) + 4-methoxy-2-nitroaniline (96-96-8) → 2-chloro-N-(4-methoxy-2-nitrophenyl)acetamide (3223-77-6)

Guidance literature:

Reference yield:

N-(4-methoxyphenyl)-2-chloroacetamide (22303-36-2) → 2-chloro-N-(4-methoxy-2-nitrophenyl)acetamide (3223-77-6) + 2-chloro-N-(4-methoxy-3-nitrophenyl)acetamide

Guidance literature:

With nitric acid; acetic acid; at 10 - 30 ℃;

Reference yield:

acetic acid (64-19-7,77671-22-8) + N-(4-methoxyphenyl)-2-chloroacetamide (22303-36-2) → 2-chloro-N-(4-methoxy-2-nitrophenyl)acetamide (3223-77-6) + 2-chloro-N-(4-methoxy-3-nitrophenyl)acetamide

Guidance literature:

at 10 - 30 ℃;

upstream raw materials:

chloroacetyl chloride

4-methoxy-2-nitroaniline

N-(4-methoxyphenyl)-2-chloroacetamide

ethanol

Downstream raw materials:

piperidino-acetic acid-(4-methoxy-2-nitro-anilide)

chloro-acetic acid-(4-methoxy-2,3-dinitro-anilide)

chloro-acetic acid-(4-methoxy-2,5-dinitro-anilide)

4-methoxy-2-nitroaniline