N-(2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzyl)acetamide

Base Information

Chemical Name:N-(2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzyl)acetamide
CAS No.:1338473-74-7
Molecular Formula:C₁₉H₁₃BrCl₃F₃N₂O₂
Molecular Weight:544.583
Hs Code.:

Synonyms:N-(2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzyl)acetamide

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Chemical Property of N-(2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzyl)acetamide

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Technology Process of N-(2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzyl)acetamide

There total 12 articles about N-(2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1338473-96-3
(2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)methanamine

: 75-36-5
acetyl chloride

: 1338473-74-7
N-(2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzyl)acetamide

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

Reference yield:

: 148547-19-7
4-Bromo-3-methylbenzoic acid methyl ester

: 1338473-74-7
N-(2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzyl)acetamide

Guidance literature:: Multi-step reaction with 11 steps

1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / Reflux

2: sodium azide / dimethyl sulfoxide / 4 h / 20 °C

3: triphenylphosphine; water / tetrahydrofuran / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C

5: sodium tetrahydroborate; methanol / tetrahydrofuran / 3.33 h / 40 - 45 °C / Inert atmosphere

6: Dess-Martin periodane / dichloromethane / 2.33 h / 0 - 20 °C

7: hydroxylamine hydrochloride; sodium acetate / ethanol / 4 h / 20 °C

8: N-chloro-succinimide / N,N-dimethyl-formamide / 12 h / 20 °C

9: sodium hydrogencarbonate / 12 h / 20 °C

10: trifluoroacetic acid / dichloromethane / 20 °C

11: pyridine / N,N-dimethyl-formamide / 0.17 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; N-chloro-succinimide; N-Bromosuccinimide; sodium azide; hydroxylamine hydrochloride; water; sodium acetate; sodium hydrogencarbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 862248-93-9
(3,4,5-trichlorophenyl)boronic acid

: 1338473-74-7
N-(2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / Reflux

2: sodium hydrogencarbonate / 12 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

4: pyridine / N,N-dimethyl-formamide / 0.17 h / 20 °C

With pyridine; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;