ethyl-2-((4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridine-2-yl)phenoxy)carbonylamino)-3-(3,4-dihydroxyphenyl)propanoate

Base Information

Chemical Name:ethyl-2-((4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridine-2-yl)phenoxy)carbonylamino)-3-(3,4-dihydroxyphenyl)propanoate
CAS No.:1402402-87-2
Molecular Formula:C₃₃H₃₆Cl₂N₄O₇
Molecular Weight:671.577
Hs Code.:

Synonyms:ethyl-2-((4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridine-2-yl)phenoxy)carbonylamino)-3-(3,4-dihydroxyphenyl)propanoate

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Chemical Property of ethyl-2-((4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridine-2-yl)phenoxy)carbonylamino)-3-(3,4-dihydroxyphenyl)propanoate

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Technology Process of ethyl-2-((4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridine-2-yl)phenoxy)carbonylamino)-3-(3,4-dihydroxyphenyl)propanoate

There total 1 articles about ethyl-2-((4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridine-2-yl)phenoxy)carbonylamino)-3-(3,4-dihydroxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1257411-78-1
4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

: 23234-41-5
L-Dopa ethyl ester hydrochloride

: 1402402-87-2
ethyl-2-((4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridine-2-yl)phenoxy)carbonylamino)-3-(3,4-dihydroxyphenyl)propanoate

Guidance literature:: In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.ijpharm.2012.08.023

Reference yield:

: 1402402-87-2
ethyl-2-((4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridine-2-yl)phenoxy)carbonylamino)-3-(3,4-dihydroxyphenyl)propanoate

: 1073119-12-6
N,N-di-n-propyl-[2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)]acetamide

Guidance literature:: With methanol; In aq. phosphate buffer; at 37 ℃; pH=7.4;
DOI:10.1016/j.ijpharm.2012.08.023

Reference yield:

: 1402402-87-2
ethyl-2-((4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridine-2-yl)phenoxy)carbonylamino)-3-(3,4-dihydroxyphenyl)propanoate

: 1257411-78-1
4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / aq. phosphate buffer / 37 °C / pH 7.4

2: triethylamine / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere

With methanol; triethylamine; In tetrahydrofuran; aq. phosphate buffer;
DOI:10.1016/j.ijpharm.2012.08.023