4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

Base Information

Chemical Name:4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate
CAS No.:1257411-78-1
Molecular Formula:C₂₈H₂₆Cl₂N₄O₆
Molecular Weight:585.444
Hs Code.:

Synonyms:4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

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Chemical Property of 4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

Chemical Property:

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Technology Process of 4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

There total 3 articles about 4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5070-13-3
bis-(p-nitrophenyl) carbonate

: 1073119-12-6
N,N-di-n-propyl-[2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)]acetamide

: 1257411-78-1
4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 50 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.ijpharm.2012.08.023

Reference yield:

: 1073119-12-6
N,N-di-n-propyl-[2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)]acetamide

: 7693-46-1
4-Nitrophenyl chloroformate

: 1257411-78-1
4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1021/mp100235w

Reference yield:

: 1402402-87-2
ethyl-2-((4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridine-2-yl)phenoxy)carbonylamino)-3-(3,4-dihydroxyphenyl)propanoate

: 1257411-78-1
4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / aq. phosphate buffer / 37 °C / pH 7.4

2: triethylamine / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere

With methanol; triethylamine; In tetrahydrofuran; aq. phosphate buffer;
DOI:10.1016/j.ijpharm.2012.08.023