2-[4-(2-Acetylamino-2-benzyloxycarbonyl-ethyl)-benzyl]-4,4-dimethoxy-3-oxo-pentanoic acid methyl ester

Base Information

Chemical Name:2-[4-(2-Acetylamino-2-benzyloxycarbonyl-ethyl)-benzyl]-4,4-dimethoxy-3-oxo-pentanoic acid methyl ester
CAS No.:182617-53-4
Molecular Formula:C₂₇H₃₃NO₈
Molecular Weight:499.561
Hs Code.:

Synonyms:2-[4-(2-Acetylamino-2-benzyloxycarbonyl-ethyl)-benzyl]-4,4-dimethoxy-3-oxo-pentanoic acid methyl ester

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Chemical Property of 2-[4-(2-Acetylamino-2-benzyloxycarbonyl-ethyl)-benzyl]-4,4-dimethoxy-3-oxo-pentanoic acid methyl ester

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Technology Process of 2-[4-(2-Acetylamino-2-benzyloxycarbonyl-ethyl)-benzyl]-4,4-dimethoxy-3-oxo-pentanoic acid methyl ester

There total 7 articles about 2-[4-(2-Acetylamino-2-benzyloxycarbonyl-ethyl)-benzyl]-4,4-dimethoxy-3-oxo-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6232-88-8
4-bromomethylbenzoic Acid

: 182617-53-4
2-[4-(2-Acetylamino-2-benzyloxycarbonyl-ethyl)-benzyl]-4,4-dimethoxy-3-oxo-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / BH₃*THF / tetrahydrofuran / 0 - 20 °C

2: 1) sodium ethoxide / 1) EtOH, 2) EtOH, room temperature

3: 1 N NaOH / Ambient temperature

4: 130 - 140 °C

5: aq. NaOH / ethanol

6: 92 percent / DBU / acetonitrile / Heating

7: 87 percent / Ph₃P*Br₂ / acetonitrile / Ambient temperature

8: 1) NaH / 1) DMF, 0 deg C, 1 h, 2) DMF, room temperature, overnight

With sodium hydroxide; borane-THF; sodium ethanolate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine dibromide 1:1 addition complex; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/0960-894X(96)00349-6

Reference yield:

: 15742-86-6
N-Acetyl (4-hydroxymethyl)-DL-phenylalanine

: 182617-53-4
2-[4-(2-Acetylamino-2-benzyloxycarbonyl-ethyl)-benzyl]-4,4-dimethoxy-3-oxo-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / DBU / acetonitrile / Heating

2: 87 percent / Ph₃P*Br₂ / acetonitrile / Ambient temperature

3: 1) NaH / 1) DMF, 0 deg C, 1 h, 2) DMF, room temperature, overnight

With sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine dibromide 1:1 addition complex; In acetonitrile;
DOI:10.1016/0960-894X(96)00349-6

Reference yield:

: 71831-21-5
4-(bromomethyl)benzyl alcohol

: 182617-53-4
2-[4-(2-Acetylamino-2-benzyloxycarbonyl-ethyl)-benzyl]-4,4-dimethoxy-3-oxo-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1) sodium ethoxide / 1) EtOH, 2) EtOH, room temperature

2: 1 N NaOH / Ambient temperature

3: 130 - 140 °C

4: aq. NaOH / ethanol

5: 92 percent / DBU / acetonitrile / Heating

6: 87 percent / Ph₃P*Br₂ / acetonitrile / Ambient temperature

7: 1) NaH / 1) DMF, 0 deg C, 1 h, 2) DMF, room temperature, overnight

With sodium hydroxide; sodium ethanolate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine dibromide 1:1 addition complex; In ethanol; acetonitrile;
DOI:10.1016/0960-894X(96)00349-6