ethyl 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)acetate

Base Information

• Chemical Name: ethyl 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)acetate
• CAS No.: 919467-55-3
• Molecular Formula: C₁₉H₁₇NO₆S
• Molecular Weight: 387.413
• Mol file: 919467-55-3.mol

Synonyms:ethyl 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)acetate

Chemical Property of ethyl 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)acetate

There total 4 articles about ethyl 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(4-hydroxy-1,1-dioxo-1,2-dihydro-1λ6-benzo[e][1,2]thiazin-3-yl)-phenyl-methanone (61018-80-2) + ethyl bromoacetate (105-36-2) → ethyl 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)acetate (919467-55-3)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃; for 12h;

DOI:10.1248/cpb.59.46

Reference yield:

1,1-dioxo-2-(2-oxo-2-phenyl-ethyl)-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one (15246-95-4) → ethyl 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)acetate (919467-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol; sodium / 3 h / 40 - 55 °C

1.2: 25 - 35 °C

2.1: sodium hydroxide / ethanol; water / 12 h / 20 °C

With ethanol; sodium; sodium hydroxide; In ethanol; water;

DOI:10.1248/cpb.59.46

Reference yield:

saccharin sodium salt (128-44-9) → ethyl 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)acetate (919467-55-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 4 h / 100 °C

2.1: ethanol; sodium / 3 h / 40 - 55 °C

2.2: 25 - 35 °C

3.1: sodium hydroxide / ethanol; water / 12 h / 20 °C

With ethanol; sodium; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1248/cpb.59.46

upstream raw materials:

(4-hydroxy-1,1-dioxo-1,2-dihydro-1λ⁶-benzo[e][1,2]thiazin-3-yl)-phenyl-methanone

ethyl bromoacetate

1,1-dioxo-2-(2-oxo-2-phenyl-ethyl)-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one

saccharin sodium salt

Downstream raw materials:

2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-benzylacetamide

2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-(pyridin-2-ylmethyl)acetamide

2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-(furan-2-ylmethyl)acetamide

2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-(4-fluorobenzyl)acetamide