1-[(E)-2-(4-Chloro-phenyl)-vinyl]-3-(4-hydroxy-3-methoxy-benzyl)-thiourea

Base Information

Chemical Name:1-[(E)-2-(4-Chloro-phenyl)-vinyl]-3-(4-hydroxy-3-methoxy-benzyl)-thiourea
CAS No.:184003-09-6
Molecular Formula:C₁₇H₁₇ClN₂O₂S
Molecular Weight:348.853
Hs Code.:

Synonyms:1-[(E)-2-(4-Chloro-phenyl)-vinyl]-3-(4-hydroxy-3-methoxy-benzyl)-thiourea

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Chemical Property of 1-[(E)-2-(4-Chloro-phenyl)-vinyl]-3-(4-hydroxy-3-methoxy-benzyl)-thiourea

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Technology Process of 1-[(E)-2-(4-Chloro-phenyl)-vinyl]-3-(4-hydroxy-3-methoxy-benzyl)-thiourea

There total 5 articles about 1-[(E)-2-(4-Chloro-phenyl)-vinyl]-3-(4-hydroxy-3-methoxy-benzyl)-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 68215-54-3
(E)-2-(4-chlorophenyl)ethenyl isothiocyanate

: 7149-10-2
vanillylamine hydrochloride

: 184003-09-6
1-[(E)-2-(4-Chloro-phenyl)-vinyl]-3-(4-hydroxy-3-methoxy-benzyl)-thiourea

Guidance literature:: With sodium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1021/jm960512h

Reference yield:

: 41870-82-0
2-amino-1-(4-chlorophenyl)ethanol

: 184003-09-6
1-[(E)-2-(4-Chloro-phenyl)-vinyl]-3-(4-hydroxy-3-methoxy-benzyl)-thiourea

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / thionyl chloride / CHCl₃ / 3 h / Heating

2: 84 percent / aq. NaOH / CH₂Cl₂ / 0.5 h

3: 20 percent / Et₃N / toluene / 36 h / 100 °C

4: 87 percent / 5 M NaOH / dimethylformamide

With sodium hydroxide; thionyl chloride; triethylamine; In dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm960512h

Reference yield:

: 13014-48-7
4-chlorobenzoyl cyanide

: 184003-09-6
1-[(E)-2-(4-Chloro-phenyl)-vinyl]-3-(4-hydroxy-3-methoxy-benzyl)-thiourea

Guidance literature:: Multi-step reaction with 5 steps

1: 33 percent / LiAlH₄ / diethyl ether / 1.) RT, 18 h, 2.) reflux, 6 h

2: 51 percent / thionyl chloride / CHCl₃ / 3 h / Heating

3: 84 percent / aq. NaOH / CH₂Cl₂ / 0.5 h

4: 20 percent / Et₃N / toluene / 36 h / 100 °C

5: 87 percent / 5 M NaOH / dimethylformamide

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; triethylamine; In diethyl ether; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm960512h