2-(4-Chlorophenyl)-5-pyridin-3-yl-1,3,4-oxadiazole

Base Information

Chemical Name:2-(4-Chlorophenyl)-5-pyridin-3-yl-1,3,4-oxadiazole
CAS No.:56352-94-4
Molecular Formula:C₁₃H₈ClN₃O
Molecular Weight:257.679
Hs Code.:
DSSTox Substance ID:DTXSID901324086
ChEMBL ID:CHEMBL1510128

Synonyms:2-(4-chlorophenyl)-5-pyridin-3-yl-1,3,4-oxadiazole;MLS001211835;56352-94-4;3-[5-(4-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-pyridine;SMR000517525;2-(4-chlorophenyl)-5-(3-pyridyl)-1,3,4-oxadiazole;cid_740480;F1424-0233;SCHEMBL1422502;CHEMBL1510128;BDBM93878;2-(4-chlorophenyl)-5-(pyridin-3-yl)-1,3,4-oxadiazole;DTXSID901324086;HMS2844L22;AKOS000589751;2-(3-pyridyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole;Z50151022;2-(4-chlorophenyl)-5-(3-pyridinyl)-1,3,4-oxadiazole

Suppliers and Price of 2-(4-Chlorophenyl)-5-pyridin-3-yl-1,3,4-oxadiazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-Chlorophenyl)-5-pyridin-3-yl-1,3,4-oxadiazole

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:257.0355896
Heavy Atom Count:18
Complexity:271

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CN=C1)C2=NN=C(O2)C3=CC=C(C=C3)Cl

Technology Process of 2-(4-Chlorophenyl)-5-pyridin-3-yl-1,3,4-oxadiazole

There total 5 articles about 2-(4-Chlorophenyl)-5-pyridin-3-yl-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 56352-79-5
4-cchlorbenzoic acid(pyridine-3-carbonyl)hydrazide

: 56352-94-4
3-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)pyridine

Guidance literature:: With trichlorophosphate; at 100 ℃;
DOI:10.1002/hc.20285

Reference yield: 69.0%

: 553-53-7
Nicotinic acid hydrazide

: 74-11-3
para-chlorobenzoic acid

: 56352-94-4
3-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)pyridine

Guidance literature:: With trichlorophosphate; In water; for 9h; Reflux;
DOI:10.1007/s00044-012-0129-4

Reference yield:

: 614-18-6
3-pyridinecarboxylic acid ethyl ester

: 56352-94-4
3-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine monohydrate / ethanol

2: 85 percent / pyridine / CH₂Cl₂ / 3 h / 20 °C

3: 82 percent / POCl₃ / 100 °C

With pyridine; hydrazine hydrate; trichlorophosphate; In ethanol; dichloromethane;
DOI:10.1002/hc.20285