56352-79-5Relevant academic research and scientific papers
Synthesis and in vitro urease inhibitory activity of benzohydrazide derivatives, in silico and kinetic studies
Abbas, Azhar,Ali, Basharat,Kanwal,Khan, Khalid Mohammed,Iqbal, Jamshed,ur Rahman, Shafiq,Zaib, Sumera,Perveen, Shahnaz
, p. 163 - 177 (2018/10/21)
Benzohydrazide derivatives 1–43 were synthesized via “one-pot” reaction and structural characterization of these synthetic derivatives was carried out by different spectroscopic techniques such as 1H NMR and EI-MS. The synthetic molecules were evaluated for their in vitro urease inhibitory activity. All synthetic derivatives showed good inhibitory activities in the range of (IC50 = 0.87 ± 0.31–19.0 ± 0.25 μM) as compared to the standard thiourea (IC50 = 21.25 ± 0.15 μM), except seven compounds 17, 18, 23, 24, 29, 30, and 41 which were found to be inactive. The most active compound of the series was compound 36 (IC50 = 0.87 ± 0.31 μM) having two chloro groups at meta positions of ring A and methoxy group at para position of ring B. The structure–activity relationship (SAR) of the active compounds was established on the basis of different substituents and their positions in the molecules. Kinetic studies of the active compounds revealed that compounds can inhibit enzyme via competitive and noncompetitive modes. In silico study was also performed to understand the binding interactions of the molecules (ligand) with the active site of enzyme.
Synthesis and characterization of new blue-greenish electroluminescent materials based on 1,3,4-oxadiazole-triazolopyridinone hybrids
Shin, Ming-Hsiang,Wong, Fung Fuh,Lin, Chun-Min,Chen, Wen-Yi,Yeh, Mou-Yung
, p. 212 - 219 (2008/02/07)
New functionalized oxadiazole-triazolopyridinone derivatives were synthesized via arcycloaddition. With the chromophores of triazolopyridinone, the photoluminescence spectra of these compounds in dichloromethane solution showed emission peaks between 430 and 520 nm. Following the spectroscopic studies, and the measurements of cyclic voltammogram, 1,3,4-oxadiazole- triazolopyridinone hybrids possess a great potential as highly efficient, blue-greenish, organic light-emitting devices materials.
