(2R,3S)-5-methylene-3-nitro-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran

Base Information

• Chemical Name: (2R,3S)-5-methylene-3-nitro-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran
• CAS No.: 951127-20-1
• Molecular Formula: C₁₂H₁₀F₃NO₃
• Molecular Weight: 273.212

Synonyms:(2R,3S)-5-methylene-3-nitro-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran

Chemical Property of (2R,3S)-5-methylene-3-nitro-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran

Chemical Property:

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Technology Process of (2R,3S)-5-methylene-3-nitro-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran

There total 11 articles about (2R,3S)-5-methylene-3-nitro-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-5-methylene-3-nitro-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran → (2R,3S)-5-methylene-3-nitro-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran (951127-20-1)

Guidance literature:

In n-heptane; isopropyl alcohol; Resolution of racemate;

Reference yield:

trans-5-methylene-3-nitro-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran → (2R,3S)-5-methylene-3-nitro-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran (951127-20-1)

Guidance literature:

Purification / work up;

Reference yield:

trans-5-methylene-3-nitro-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran → (2R,3S)-5-methylene-3-nitro-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran (951127-20-1) + (2S,3R)-5-methylene-3-nitro-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran

Guidance literature:

With ChiralCel OD; In n-heptane; isopropyl alcohol; Purification / work up; Resolution of racemate;

upstream raw materials:

1,8-diazabicyclo[5.4.0]undec-7-ene

phenyl 2,4,5-trifluorobenzoate

2-nitro-1-(2,4,5-trifluorophenyl)ethanone

2,4,5-trifluorobenzoyl chloride

Downstream raw materials:

(2R,3S)-5-methylene-2-(2,4,5-tri fluorophenyl)tetrahydro-2H-pyran-3-amine

tert-butyl [(2R,3S)-5-methylene-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl]carbamate

tert-butyl [(2R,3S)-5-hydroxy-5-(hydroxymethyl)-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl]carbamate

tert-butyl ((2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl)carbamate

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