Technology Process of (2R,3S)-5-methylene-2-(2,4,5-tri fluorophenyl)tetrahydro-2H-pyran-3-amine
There total 6 articles about (2R,3S)-5-methylene-2-(2,4,5-tri fluorophenyl)tetrahydro-2H-pyran-3-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2R,3S)-5-methylene-3-nitro-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran;
With
hydrogenchloride; zinc;
In
ethanol; water;
for 1h;
With
sodium hydroxide;
In
diethyl ether; ethanol; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Cooling with ice
2.1: sodium hydride / N,N-dimethyl-formamide; hexane; mineral oil / 2.5 h / 20 °C / Inert atmosphere
2.2: 0 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2.5 h / 60 °C
4.1: sodium tetrahydroborate / isopropyl alcohol; chloroform / 0.5 h / 20 °C
4.2: 1.75 h
5.1: ChiralCel OD / isopropyl alcohol; n-heptane / Resolution of racemate
6.1: hydrogenchloride; zinc / ethanol / 1 h
With
hydrogenchloride; sodium tetrahydroborate; sodium hydride; N-ethyl-N,N-diisopropylamine; zinc;
In
ethanol; hexane; n-heptane; dichloromethane; chloroform; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate / isopropyl alcohol; chloroform / 0.5 h / 20 °C
1.2: 1.75 h
2.1: ChiralCel OD / isopropyl alcohol; n-heptane / Resolution of racemate
3.1: hydrogenchloride; zinc / ethanol / 1 h
With
hydrogenchloride; sodium tetrahydroborate; zinc;
In
ethanol; n-heptane; chloroform; isopropyl alcohol;
