Carbamic acid, [4-[(4,5-dihydro-2-thiazolyl)amino]butyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

Chemical Name:Carbamic acid, [4-[(4,5-dihydro-2-thiazolyl)amino]butyl]-, 1,1-dimethylethyl ester (9CI)
CAS No.:250663-42-4
Molecular Formula:C₁₂H₂₃N₃O₂S
Molecular Weight:273.4
Hs Code.:
Mol file:250663-42-4.mol

Synonyms:Carbamic acid, [4-[(4,5-dihydro-2-thiazolyl)amino]butyl]-, 1,1-dimethylethyl ester (9CI)

Suppliers and Price of Carbamic acid, [4-[(4,5-dihydro-2-thiazolyl)amino]butyl]-, 1,1-dimethylethyl ester (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [4-[(4,5-dihydro-2-thiazolyl)amino]butyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

PSA：88.02000
LogP:2.20110

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [4-[(4,5-dihydro-2-thiazolyl)amino]butyl]-, 1,1-dimethylethyl ester (9CI)

There total 3 articles about Carbamic acid, [4-[(4,5-dihydro-2-thiazolyl)amino]butyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 106-93-4
ethylene dibromide

: 250663-40-2
1,1-dimethylethoxycarbonyl N-(4-(thioureido)butyl)carbamate

: 250663-42-4
4,5-dihydro-2-(4-(1,1-dimethylethoxycarbonylamino)butylamino)thiazole

Guidance literature:: With potassium carbonate; In tetrahydrofuran; for 16h; Heating;
DOI:10.1016/S0968-0896(99)00136-4

Reference yield:

: 68076-36-8
1-amino-4-[(tert-butyloxycarbonyl)amino]butane

: 250663-42-4
4,5-dihydro-2-(4-(1,1-dimethylethoxycarbonylamino)butylamino)thiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N / tetrahydrofuran / 2 h / 0 °C

1.2: 80 percent / 16 h / 20 °C

2.1: 51 percent / NH₃ / methanol / 0 - 20 °C

3.1: 40 percent / K₂CO₃ / tetrahydrofuran / 16 h / Heating

With ammonia; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; 1.1: Addition / 1.2: Methylation / 2.1: Substitution / 3.1: Cycloaddition;
DOI:10.1016/S0968-0896(99)00136-4

Reference yield:

: 250663-38-8
methyl N-(4-(1,1-dimethylethoxycarbonylamino)butyl)dithiocarbamate

: 250663-42-4
4,5-dihydro-2-(4-(1,1-dimethylethoxycarbonylamino)butylamino)thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / NH₃ / methanol / 0 - 20 °C

2: 40 percent / K₂CO₃ / tetrahydrofuran / 16 h / Heating

With ammonia; potassium carbonate; In tetrahydrofuran; methanol; 1: Substitution / 2: Cycloaddition;
DOI:10.1016/S0968-0896(99)00136-4