(2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid tosylate salt

Base Information

• Chemical Name: (2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid tosylate salt
• CAS No.: 948897-66-3
• Molecular Formula: C₇H₈O₃S*C₂₄H₂₀Cl₂N₂O₅
• Molecular Weight: 659.544
• Mol file: 948897-66-3.mol

Synonyms:(2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid tosylate salt

Chemical Property of (2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid tosylate salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid tosylate salt

There total 13 articles about (2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid tosylate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

(2S)-2-((6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl)oxy)propanoic acid methyl ester + toluene-4-sulfonic acid (104-15-4) → (2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid tosylate salt (948897-66-3)

Guidance literature:

(2S)-2-((6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl)oxy)propanoic acid methyl ester; With sodium hydroxide; water; at 15 - 25 ℃; for 2 - 3h;

With hydrogenchloride; water; pH=2 - 3;

toluene-4-sulfonic acid; In ethyl acetate; at 15 - 25 ℃; for 10h;

Reference yield: 90.5%

(2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid (909543-30-2) + toluene-4-sulfonic acid (104-15-4) → (2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid tosylate salt (948897-66-3)

Guidance literature:

In ethyl acetate; at 15 - 25 ℃; for 10h;

Reference yield:

methyl 2-chloro-6-(4-chlorophenoxy)nicotinate (906794-87-4) → (2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid tosylate salt (948897-66-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride / tetrahydrofuran; diethyl ether / 0.75 h / 25 - 28 °C

1.2: 0.25 h

2.1: sodium hydroxide; water / methanol / 2.5 h / 68 °C

2.2: 68 °C

3.1: trifluorormethanesulfonic acid; trifluoroacetic anhydride / 40 - 55 °C

3.2: 1 h / 0 - 50 °C

4.1: hydrogen bromide; sodium iodide / water; acetic acid / 24.5 h / 95 - 100 °C

5.1: hydroxylamine; boric acid / propan-1-ol / 1 h / 90 - 92 °C / Heating / reflux

5.2: 6 h / 93 - 97 °C

6.1: sodium hydroxide; water / acetonitrile / 2 - 3 h / 15 - 25 °C

6.2: pH 2 - 3

7.1: ethyl acetate / 10 h / 15 - 25 °C

With sodium hydroxide; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; trifluorormethanesulfonic acid; water; hydrogen bromide; hydroxylamine; boric acid; trifluoroacetic anhydride; sodium iodide; In tetrahydrofuran; methanol; propan-1-ol; diethyl ether; water; acetic acid; ethyl acetate; acetonitrile; 3.1: Friedel Crafts Acylation;

upstream raw materials:

(2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid

toluene-4-sulfonic acid

methyl 2-chloro-6-(4-chlorophenoxy)nicotinate

2,6-dichloropyridine-3-carboxylic acid