(2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid

Base Information

Chemical Name:(2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid
CAS No.:909543-30-2
Molecular Formula:C₂₄H₂₀Cl₂N₂O₅
Molecular Weight:487.339
Hs Code.:

Synonyms:(2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid

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Chemical Property of (2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid

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Technology Process of (2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid

There total 11 articles about (2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S)-2-((6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl)oxy)propanoic acid methyl ester

: 909543-30-2
(2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid

Guidance literature:: With methanol; sodium hydroxide; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: C₂₁H₁₈Cl₂N₂O₄

: 909543-30-2
(2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid

Guidance literature:: C₂₁H₁₈Cl₂N₂O₄; With sodium hydroxide; water; In acetonitrile; at 15 - 25 ℃; for 2 - 3h;

With hydrogenchloride; In water; acetonitrile; pH=2 - 3; Product distribution / selectivity;

Reference yield:

: 906794-87-4
methyl 2-chloro-6-(4-chlorophenoxy)nicotinate

: 909543-30-2
(2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride / tetrahydrofuran; diethyl ether / 0.75 h / 25 - 28 °C

1.2: 0.25 h

2.1: sodium hydroxide; water / methanol / 2.5 h / 68 °C

2.2: 68 °C

3.1: trifluorormethanesulfonic acid; trifluoroacetic anhydride / 40 - 55 °C

3.2: 1 h / 0 - 50 °C

4.1: hydrogen bromide; sodium iodide / water; acetic acid / 24.5 h / 95 - 100 °C

5.1: hydroxylamine; boric acid / propan-1-ol / 1 h / 90 - 92 °C / Heating / reflux

5.2: 6 h / 93 - 97 °C

6.1: sodium hydroxide; water / acetonitrile / 2 - 3 h / 15 - 25 °C

6.2: pH 2 - 3

With sodium hydroxide; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; trifluorormethanesulfonic acid; water; hydrogen bromide; hydroxylamine; boric acid; trifluoroacetic anhydride; sodium iodide; In tetrahydrofuran; methanol; propan-1-ol; diethyl ether; water; acetic acid; acetonitrile; 3.1: Friedel Crafts Acylation;