methyl 1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylate

Base Information

• Chemical Name: methyl 1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylate
• CAS No.: 1476068-47-9
• Molecular Formula: C₂₂H₂₃BrN₂O₄
• Molecular Weight: 459.34
• Mol file: 1476068-47-9.mol

Synonyms:methyl 1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylate

Chemical Property of methyl 1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylate

There total 2 articles about methyl 1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

methyl 4-(2,6-dimethoxyphenyl)-2,4-dioxobutyrate (1476068-60-6) + 4-bromo-2-isopropyl-aniline (81090-34-8) → methyl 1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylate (1476068-47-9)

Guidance literature:

4-bromo-2-isopropyl-aniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃;

With tin(II) chloride dihdyrate; In water; at 0 ℃; for 0.5h;

methyl 4-(2,6-dimethoxyphenyl)-2,4-dioxobutyrate; In ethanol; water; for 0.333333h; Reflux;

DOI:10.1055/s-0033-1338497

Reference yield:

2-isopropylaniline (643-28-7) → methyl 1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylate (1476068-47-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium acetate; N-Bromosuccinimide / acetonitrile / 0.17 h / 20 °C

2.1: hydrogenchloride; sodium nitrite / water / 0 °C

2.2: 0.5 h / 0 °C

2.3: 0.33 h / Reflux

With hydrogenchloride; N-Bromosuccinimide; ammonium acetate; sodium nitrite; In water; acetonitrile;

DOI:10.1055/s-0033-1338497

Reference yield: 99.0%

methyl 1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylate (1476068-47-9) → 1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid (1279881-34-3)

Guidance literature:

With water; potassium hydroxide; In 1,4-dioxane; for 4h; Reflux;

DOI:10.1055/s-0033-1338497

upstream raw materials:

2-isopropylaniline

methyl 4-(2,6-dimethoxyphenyl)-2,4-dioxobutyrate

4-bromo-2-isopropyl-aniline

Downstream raw materials:

1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid

2-({[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid

tert-butyl N-{[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}-L-leucinate

N-{[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}-L-leucine