[3-(2-chloro-5-cyclopropyl-pyriτnidin-4-yloxy)-propyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[3-(2-chloro-5-cyclopropyl-pyriτnidin-4-yloxy)-propyl]-carbamic acid tert-butyl ester
CAS No.:1190380-03-0
Molecular Formula:C₁₅H₂₂ClN₃O₃
Molecular Weight:327.811
Hs Code.:

Synonyms:[3-(2-chloro-5-cyclopropyl-pyriτnidin-4-yloxy)-propyl]-carbamic acid tert-butyl ester

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Chemical Property of [3-(2-chloro-5-cyclopropyl-pyriτnidin-4-yloxy)-propyl]-carbamic acid tert-butyl ester

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Technology Process of [3-(2-chloro-5-cyclopropyl-pyriτnidin-4-yloxy)-propyl]-carbamic acid tert-butyl ester

There total 1 articles about [3-(2-chloro-5-cyclopropyl-pyriτnidin-4-yloxy)-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 1190379-86-2
2,4-dichloro-5-cyclopropylpyrimidine

: 1190380-03-0
[3-(2-chloro-5-cyclopropyl-pyriτnidin-4-yloxy)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: N-tert-butoxycarbonyl-3-aminopropanol; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

2,4-dichloro-5-cyclopropylpyrimidine; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

Reference yield: 20.0%

: 372-19-0
meta-fluoroaniline

: 1190380-03-0
[3-(2-chloro-5-cyclopropyl-pyriτnidin-4-yloxy)-propyl]-carbamic acid tert-butyl ester

: 1190380-04-1
{3-[5-cyclopropyl-2-(3-fluoro-phenylamino)-pyrimidin-4-yloxy]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: With acetic acid; In butan-1-ol; at 150 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 1190380-03-0
[3-(2-chloro-5-cyclopropyl-pyriτnidin-4-yloxy)-propyl]-carbamic acid tert-butyl ester

: 1190380-05-2
[4-(3-amino-propoxy)-5-cyclopropyl-pyrimidin-2-yl]-(3-fluoro-phenyl)-amine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / butan-1-ol / 0.25 h / 150 °C / Microwave irradiation

2: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; acetic acid; In 1,4-dioxane; butan-1-ol;