2-amino-6-chloro-9-<(1-benzyloxymethyl-3-diethylphosphono)-1-propyloxymethyl>-9H-purine

Base Information

Chemical Name:2-amino-6-chloro-9-<(1-benzyloxymethyl-3-diethylphosphono)-1-propyloxymethyl>-9H-purine
CAS No.:156569-08-3
Molecular Formula:C₂₁H₂₉ClN₅O₅P
Molecular Weight:497.919
Hs Code.:

Synonyms:2-amino-6-chloro-9-<(1-benzyloxymethyl-3-diethylphosphono)-1-propyloxymethyl>-9H-purine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-amino-6-chloro-9-<(1-benzyloxymethyl-3-diethylphosphono)-1-propyloxymethyl>-9H-purine

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Technology Process of 2-amino-6-chloro-9-<(1-benzyloxymethyl-3-diethylphosphono)-1-propyloxymethyl>-9H-purine

There total 5 articles about 2-amino-6-chloro-9-<(1-benzyloxymethyl-3-diethylphosphono)-1-propyloxymethyl>-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 131853-16-2
2-amino-6-chloropurine sodium salt

: 150943-45-6
(4-Benzyloxy-3-chloromethoxy-butyl)-phosphonic acid diethyl ester

: 156569-08-3
2-amino-6-chloro-9-<(1-benzyloxymethyl-3-diethylphosphono)-1-propyloxymethyl>-9H-purine

Guidance literature:: In N,N-dimethyl-formamide; at -50 - -20 ℃; for 1h;
DOI:10.1080/15257779408013261

Reference yield:

: 2930-05-4
Benzyloxymethyl-oxiran

: 156569-08-3
2-amino-6-chloro-9-<(1-benzyloxymethyl-3-diethylphosphono)-1-propyloxymethyl>-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) nBuLi, BF₃*Et₂O / 1.) hexane, THF, -78 deg C, 40 min, 2.) -78 deg C, 30 min

2: HCl gas / 1,2-dichloro-ethane / 2 h / -10 °C

3: 37 percent / dimethylformamide / 1 h / -50 - -20 °C

With hydrogenchloride; n-butyllithium; boron trifluoride diethyl etherate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1080/15257779408013261

Reference yield:

: 683-08-9
Diethyl methylphosphonate

: 156569-08-3
2-amino-6-chloro-9-<(1-benzyloxymethyl-3-diethylphosphono)-1-propyloxymethyl>-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) nBuLi, BF₃*Et₂O / 1.) hexane, THF, -78 deg C, 40 min, 2.) -78 deg C, 30 min

2: HCl gas / 1,2-dichloro-ethane / 2 h / -10 °C

3: 37 percent / dimethylformamide / 1 h / -50 - -20 °C

With hydrogenchloride; n-butyllithium; boron trifluoride diethyl etherate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1080/15257779408013261