C₄₃H₄₃N₅O₈

Base Information

• Chemical Name: C₄₃H₄₃N₅O₈
• CAS No.: 1453097-84-1
• Molecular Formula: C₄₃H₄₃N₅O₈
• Molecular Weight: 757.843
• Mol file: 1453097-84-1.mol

Synonyms:C₄₃H₄₃N₅O₈

Chemical Property of C₄₃H₄₃N₅O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₃H₄₃N₅O₈

There total 11 articles about C₄₃H₄₃N₅O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C49H57N5O8Si (1453097-83-0) → C43H43N5O8 (1453097-84-1)

Guidance literature:

With acetic acid; In water;

DOI:10.1016/j.bmcl.2013.06.028

Reference yield:

6-methoxypyridine-2-carbaldehyde (54221-96-4) → C43H43N5O8 (1453097-84-1)

Guidance literature:

Multi-step reaction with 5 steps

1: N,N',N'-trimethylenediamine; n-butyllithium / tetrahydrofuran; hexane; cyclohexane

2: bis-triphenylphosphine-palladium(II) chloride; copper(II) oxide / N,N-dimethyl-formamide / 110 °C

3: sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene / tert-butyl alcohol; acetonitrile; water

4: dicyclohexyl-carbodiimide; dmap; benzotriazol-1-ol / N,N-dimethyl-formamide

5: acetic acid / water

With dmap; bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; n-butyllithium; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; benzotriazol-1-ol; N,N',N'-trimethylenediamine; acetic acid; dicyclohexyl-carbodiimide; copper(II) oxide; In tetrahydrofuran; hexane; cyclohexane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2013.06.028

Reference yield:

benzyl 2-(2-formyl-6-methoxy-3-pyridyl)-5-((1(S)-t-butyldimethylsilyloxymethyl-2,2-dimethylpropyl)carbamoyl)benzoate → C43H43N5O8 (1453097-84-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene / tert-butyl alcohol; acetonitrile; water

2: dicyclohexyl-carbodiimide; dmap; benzotriazol-1-ol / N,N-dimethyl-formamide

3: acetic acid / water

With dmap; sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; In water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2013.06.028

upstream raw materials:

6-methoxypyridine-2-carbaldehyde

(2-formyl-6-methoxy3-pyridyl)tributylstannane

3-[4-(1(S)-t-butyldimethylsilyloxymethyl-2,2-dimethylpropylcarbamoyl)-2-benzyloxycarbonylphenyl]-6-methoxy-2-pyridinecarboxylic acid

2-hydroxy-5-formylbenzoic acid