4-Amino-2-(2-carboxyphenyl)quinoline Hydrochloride

Base Information

Chemical Name:4-Amino-2-(2-carboxyphenyl)quinoline Hydrochloride
CAS No.:132869-05-7
Molecular Formula:C₁₆H₁₂N₂O₂*ClH
Molecular Weight:300.744
Hs Code.:

Synonyms:4-Amino-2-(2-carboxyphenyl)quinoline Hydrochloride

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Chemical Property of 4-Amino-2-(2-carboxyphenyl)quinoline Hydrochloride

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Technology Process of 4-Amino-2-(2-carboxyphenyl)quinoline Hydrochloride

There total 8 articles about 4-Amino-2-(2-carboxyphenyl)quinoline Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 132869-04-6
5-Iminoisoindolo<2,1-a>quinolin-11(5H)-one Phosphorate

: 132869-05-7
4-Amino-2-(2-carboxyphenyl)quinoline Hydrochloride

Guidance literature:: With hydrogenchloride; at 40 ℃; for 0.166667h;
DOI:10.1248/cpb.38.3024

Reference yield:

: 520-03-6
N-phenylphthalimide

: 132869-05-7
4-Amino-2-(2-carboxyphenyl)quinoline Hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / NaBH₄ / methanol; tetrahydrofuran / 2 h / 0 - 5 °C

2: toluene / 1 h / Heating

3: K₂CO₃ / methanol; H₂O / 2 h / Heating

4: 87 percent / SOCl₂ / 0.5 h / 70 °C

5: 95 percent / AlCl₃, CH₃COCl / 1,2-dichloro-ethane / 1 h / Ambient temperature

6: 83 percent / H₂NOH*HCl, NaOAc / aq. ethanol / 2 h / Heating

7: 49 percent / phosphoric acid, acetic anhydride / a) 80 deg C, 0.5 h; b) 100 deg C, 18 h

8: 92 percent / 10percent HCl / 0.17 h / 40 °C

With hydrogenchloride; sodium tetrahydroborate; aluminium trichloride; thionyl chloride; phosphoric acid; hydroxylamine hydrochloride; sodium acetate; acetic anhydride; potassium carbonate; acetyl chloride; In tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; toluene;
DOI:10.1248/cpb.38.3024

Reference yield:

: 18167-15-2
3-hydroxy-2-phenylisoindolin-1-one

: 132869-05-7
4-Amino-2-(2-carboxyphenyl)quinoline Hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: toluene / 1 h / Heating

2: K₂CO₃ / methanol; H₂O / 2 h / Heating

3: 87 percent / SOCl₂ / 0.5 h / 70 °C

4: 95 percent / AlCl₃, CH₃COCl / 1,2-dichloro-ethane / 1 h / Ambient temperature

5: 83 percent / H₂NOH*HCl, NaOAc / aq. ethanol / 2 h / Heating

6: 49 percent / phosphoric acid, acetic anhydride / a) 80 deg C, 0.5 h; b) 100 deg C, 18 h

7: 92 percent / 10percent HCl / 0.17 h / 40 °C

With hydrogenchloride; aluminium trichloride; thionyl chloride; phosphoric acid; hydroxylamine hydrochloride; sodium acetate; acetic anhydride; potassium carbonate; acetyl chloride; In methanol; ethanol; water; 1,2-dichloro-ethane; toluene;
DOI:10.1248/cpb.38.3024