18167-15-2

Basic information

• Product Name: 2,3-dihydro-3-hydroxy-2-phenyl-1H-isoindol-1-one
• Synonyms: 2,3-dihydro-3-hydroxy-2-phenyl-1H-isoindol-1-one;2-Phenyl-3-hydroxyisoindoline-1-one
• CAS NO: 18167-15-2
• Molecular Formula: C₁₄H₁₁NO₂
• Molecular Weight: 225.24264
• EINECS: 242-051-3
• Mol File: 18167-15-2.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 418.7°Cat760mmHg
• Flash Point: 207°C
• Appearance: /
• Density: 1.346g/cm³
• Vapor Pressure: 9.27E-08mmHg at 25°C
• Refractive Index: 1.684
• CAS DataBase Reference: 2,3-dihydro-3-hydroxy-2-phenyl-1H-isoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydro-3-hydroxy-2-phenyl-1H-isoindol-1-one(18167-15-2)
• EPA Substance Registry System: 2,3-dihydro-3-hydroxy-2-phenyl-1H-isoindol-1-one(18167-15-2)

Safety Data

• Hazardous Substances Data: 18167-15-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron, 49, p. 929, 1993 DOI: 10.1016/S0040-4020(01)80334-3

InChI:InChI=1/C14H11NO2/c16-13-11-8-4-5-9-12(11)14(17)15(13)10-6-2-1-3-7-10/h1-9,13,16H

Upstream product

• 520-03-6 N-phenylphthalimide 
• 93-98-1 N-phenyl benzoyl amide 
• 68-12-2 N,N-dimethyl-formamide 
• 91-13-4 α,α'-dibromo-o-xylene 
• 19375-67-8 2-phenylisoindoline 
• 10282-57-2 2-bromobenzanilide 
• 85-44-9 phthalic anhydride 
• 4727-29-1 phthalanilic acid 
• 119-67-5 o-carboxybenzaldehyde 
• 62-53-3 aniline 
• 55740-87-9 3-acetoxy-2-phenylisoindol-1(3H)-one 
• 33125-69-8 (±)-3-(phenylamino)isobenzofuran-1(3H)-one 

Downstream Products

• 1159500-19-2 C₂₀H₁₉NO₄ 
• 1159500-05-6 C₂₄H₁₇NO₂ 
• 52920-25-9 1H-2,3-dihydro-3-methoxy-2-phenylisoindol-1-one 
• 189271-41-8 3-amino-2,3-dihydro-2-phenyl-1H-isoindol-1-one 

Relevant articles and documents

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Oxidative Desymmetrization of Isoindolines Realized by tert -Butyl Nitrite (TBN) Initiated Radical sp 3C-H Activation Relay (CHAR)

An oxidative desymmetrization of isoindolines was realized by TBN initiated radical sp 3C-H activation relay (CHAR), providing a series of ω-hydroxylactams in high yields. This reaction exhibits broad substrate scope and functional group tolerance, and even N -alkyl iso-indolines can be well tolerated. The mechanistic study shows that the C-H bond oxidation, dioxygen trapping and intramolecular 1,5-H shift might be the key steps to achieve the oxidative desymmetrization.

Preparation method of hydroxyl lactam

The invention discloses a preparation method of hydroxyl lactam. The hydroxyl lactam is prepared from cyclic imide shown in a formula (II) through a homogeneous catalytic hydrogenation reaction, wherein R1, R2 and R3 are respectively and independently H,

PdII/AgI-Catalyzed Room-Temperature Reaction of γ-Hydroxy Lactams: Mechanism, Scope, and Antistaphylococcal Activity

The present work reports a PdII/AgI-promoted amidoalkylation reaction involving various γ-hydroxy lactams and C/O/S nucleophiles at room temperature. The dual mode of activation of both the electrophile and nucleophile by in situ generated catalytically active cationic PdII species facilitates the reaction at room temperature. Among the synthesized isoindoline derivatives, three compounds are found to be active against vancomycin and methicillin-resistant S. aureus strain with appreciable MIC values.