DIETHYL 2,5-DIFLUOROPHENYLMALONATE

Base Information

Chemical Name:DIETHYL 2,5-DIFLUOROPHENYLMALONATE
CAS No.:247170-23-6
Molecular Formula:C₁₃H₁₄F₂O₄
Molecular Weight:272.249
Hs Code.:2917399090
Mol file:247170-23-6.mol

Synonyms:Propanedioicacid, (2,5-difluorophenyl)-, diethyl ester (9CI)

Suppliers and Price of DIETHYL 2,5-DIFLUOROPHENYLMALONATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(2,5-DIFLUOROPHENYL)MALONIC ACID DIETHYL ESTER 95.00%
1G
$ 131.25

Total 8 raw suppliers

Chemical Property of DIETHYL 2,5-DIFLUOROPHENYLMALONATE

Chemical Property:

Vapor Pressure:0.00134mmHg at 25°C
Refractive Index:1.477
Boiling Point:297.5°Cat760mmHg
PKA:9.86±0.46(Predicted)
Flash Point:129.5°C
PSA：52.60000
Density:1.232g/cm³
LogP:2.17460

Purity/Quality:

99% ^*data from raw suppliers

(2,5-DIFLUOROPHENYL)MALONIC ACID DIETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of DIETHYL 2,5-DIFLUOROPHENYLMALONATE

There total 1 articles about DIETHYL 2,5-DIFLUOROPHENYLMALONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 399-94-0
2-bromo-1,4-difluorobenzene

: 105-53-3
diethyl malonate

: 247170-23-6
diethyl 2-(2,5-difluorophenyl)malonate

Guidance literature:: diethyl malonate; With sodium hydride; In 1,4-dioxane; mineral oil; at 60 ℃; for 0.166667h; Inert atmosphere;

2-bromo-1,4-difluorobenzene; With copper(I) bromide; In 1,4-dioxane; mineral oil; at 100 ℃; for 12h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.0c01605

Reference yield:

: 61-82-5
3⁽⁵⁾-amino-1,2,4-triazole

: 247170-23-6
diethyl 2-(2,5-difluorophenyl)malonate

: sodium 6-(2,5-difluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine-5,7-bis(olate)

Guidance literature:: 3⁽⁵⁾-amino-1,2,4-triazole; diethyl 2-(2,5-difluorophenyl)malonate; With tributyl-amine; at 170 ℃; for 2h; Sealed tube;

With sodium hydroxide; In water; at 0 - 50 ℃; for 0.166667h;
DOI:10.1021/acs.jmedchem.0c01605