Multi-step reaction with 4 steps
1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 20 °C
2: diborane / tetrahydrofuran / 9 h / 0 °C / Reflux
3: hydrazine hydrate / ethanol; 1,2-dichloro-ethane / 1 h / 30 - 45 °C
4: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C
With
dmap; hydrazine hydrate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; dicyclohexyl-carbodiimide; diborane;
In
tetrahydrofuran; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.04.098