1-Phenyl-3-(phenylhydroxymethyl)-2-pyrrolidinon

Base Information

• Chemical Name: 1-Phenyl-3-(phenylhydroxymethyl)-2-pyrrolidinon
• CAS No.: 85175-03-7
• Molecular Formula: C₁₇H₁₇NO₂
• Molecular Weight: 267.327
• Mol file: 85175-03-7.mol

Synonyms:1-Phenyl-3-(phenylhydroxymethyl)-2-pyrrolidinon

Chemical Property of 1-Phenyl-3-(phenylhydroxymethyl)-2-pyrrolidinon

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Phenyl-3-(phenylhydroxymethyl)-2-pyrrolidinon

There total 4 articles about 1-Phenyl-3-(phenylhydroxymethyl)-2-pyrrolidinon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-phenyl-2-oxo-3-pyrrolidine-3-carboxylic acid (56137-52-1) + benzaldehyde (100-52-7) → 1-Phenyl-3-(phenylhydroxymethyl)-2-pyrrolidinon (85175-03-7)

Guidance literature:

In N,N-dimethyl-formamide; at 70 ℃; for 24h; Inert atmosphere;

DOI:10.1126/science.abb4129

Reference yield: 63.0%

3-Benzoyl-1-phenyl-2-pyrrolidinon (85174-90-9) → 1-Phenyl-3-(phenylhydroxymethyl)-2-pyrrolidinon (85175-03-7)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 1.5h; Ambient temperature;

Reference yield:

benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) → 1-Phenyl-3-(phenylhydroxymethyl)-2-pyrrolidinon (85175-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaH, methanol / 1) benzene, 10 min, reflux, 2) 4 h, reflux

2: 63 percent / NaBH₄ / ethanol / 1.5 h / Ambient temperature

With methanol; sodium tetrahydroborate; sodium hydride; In ethanol;

upstream raw materials:

3-Benzoyl-1-phenyl-2-pyrrolidinon

benzoic acid methyl ester

1-phenylpyrrolidin-2-one

1-phenyl-2-oxo-3-pyrrolidine-3-carboxylic acid

Downstream raw materials:

3-Benzyliden-1-phenyl-2-pyrrolidinon

Refernces

• 1、 Eiden, Fritz,Baumann, Egmont,Lotter, Hermann. "Pyran Derivatives, 96. - Benzopyranopyrrole and -pyridine Derivatives". . p. 165 - 180. Retrieved 2007/10/02.