(6R,8S)-1-(phenylsulfonyl)-5-(hydroxymethyl)-6,8-dimethyl-1,6,7,8-tetrahydrocyclopentindole

Base Information

Chemical Name:(6R,8S)-1-(phenylsulfonyl)-5-(hydroxymethyl)-6,8-dimethyl-1,6,7,8-tetrahydrocyclopentindole
CAS No.:152708-69-5
Molecular Formula:C₂₀H₂₁NO₃S
Molecular Weight:355.458
Hs Code.:

(6R,8S)-1-(phenylsulfonyl)-5-(hydroxymethyl)-6,8-dimethyl-1,6,7,8-tetrahydrocyclopent<g>indole

Synonyms:(6R,8S)-1-(phenylsulfonyl)-5-(hydroxymethyl)-6,8-dimethyl-1,6,7,8-tetrahydrocyclopentindole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6R,8S)-1-(phenylsulfonyl)-5-(hydroxymethyl)-6,8-dimethyl-1,6,7,8-tetrahydrocyclopentindole

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Technology Process of (6R,8S)-1-(phenylsulfonyl)-5-(hydroxymethyl)-6,8-dimethyl-1,6,7,8-tetrahydrocyclopentindole

There total 11 articles about (6R,8S)-1-(phenylsulfonyl)-5-(hydroxymethyl)-6,8-dimethyl-1,6,7,8-tetrahydrocyclopentindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 176979-94-5
(6R,8S)-1-Benzenesulfonyl-6,8-dimethyl-5-trityloxymethyl-1,6,7,8-tetrahydro-cyclopenta[g]indole

: 152708-69-5
(6R,8S)-1-(phenylsulfonyl)-5-(hydroxymethyl)-6,8-dimethyl-1,6,7,8-tetrahydrocyclopentindole

Guidance literature:: With (1S)-10-camphorsulfonic acid; In tetrahydrofuran; methanol; for 5h; Ambient temperature;
DOI:10.1021/jo951767q

Reference yield: 73.0%

: (R)-1-Benzenesulfonyl-6,8-dimethyl-1,6,7,8-tetrahydro-cyclopenta[g]indole-5-carboxylic acid ethyl ester

: 152784-96-8
(6R,8R)-6,8-dimethyl-1-(phenylsulfonyl)-1,6,7,8-tetrahydrocyclopentindole-5-methanol

: 152708-69-5
(6R,8S)-1-(phenylsulfonyl)-5-(hydroxymethyl)-6,8-dimethyl-1,6,7,8-tetrahydrocyclopentindole

Guidance literature:: With lithium aluminium tetrahydride;
DOI:10.1016/S0040-4039(00)74096-2

Reference yield: 10.0%

: 152708-70-8
(6R,8S)-6,8-dimethyl-1-(phenylsulfonyl)-1,6,7,8-tetrahydrocyclopentindole-5-carboxaldehyde

: 152708-69-5
(6R,8S)-1-(phenylsulfonyl)-5-(hydroxymethyl)-6,8-dimethyl-1,6,7,8-tetrahydrocyclopentindole

: (αξ,6R,8S)-6,8-dimethyl-1-(phenylsulfonyl)-α-propyl-1,6,7,8-tetrahydrocyclopentindole-5-methanol

Guidance literature:: With n-propylmagnesium bromide; In tetrahydrofuran; at -20 ℃; for 0.333333h; Yields of byproduct given;
DOI:10.1248/cpb.42.854