triethylammonium salt of 1-<5-O-(2-fluorophenyl)phosphono-2,3-O-isopropylidene-α-D-ribofuranosyl>-5,6-dimethylbenzimidazole

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Chemical Name:triethylammonium salt of 1-<5-O-(2-fluorophenyl)phosphono-2,3-O-isopropylidene-α-D-ribofuranosyl>-5,6-dimethylbenzimidazole
CAS No.:101155-36-6
Molecular Formula:C₆H₁₅N*C₂₃H₂₆FN₂O₇P
Molecular Weight:593.633
Hs Code.:

Synonyms:triethylammonium salt of 1-<5-O-(2-fluorophenyl)phosphono-2,3-O-isopropylidene-α-D-ribofuranosyl>-5,6-dimethylbenzimidazole

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Chemical Property of triethylammonium salt of 1-<5-O-(2-fluorophenyl)phosphono-2,3-O-isopropylidene-α-D-ribofuranosyl>-5,6-dimethylbenzimidazole

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Technology Process of triethylammonium salt of 1-<5-O-(2-fluorophenyl)phosphono-2,3-O-isopropylidene-α-D-ribofuranosyl>-5,6-dimethylbenzimidazole

There total 3 articles about triethylammonium salt of 1-<5-O-(2-fluorophenyl)phosphono-2,3-O-isopropylidene-α-D-ribofuranosyl>-5,6-dimethylbenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 582-60-5
5,6-dimethyl-1H-benzo[d]imida-zole

: 101155-32-2
2,3-O-isopropylidene-β-D-ribofuranose cyclic 1,5-(2-fluorophenyl)phosphate

: 101155-36-6
triethylammonium salt of 1-<5-O-(2-fluorophenyl)phosphono-2,3-O-isopropylidene-α-D-ribofuranosyl>-5,6-dimethylbenzimidazole

Guidance literature:: With n-butyllithium; tin(II) bromide; In tetrahydrofuran; hexane; at 0 - 22 ℃;
DOI:10.1246/cl.1985.1087

Reference yield:

: 67814-68-0,70266-87-4,76249-50-8,76249-51-9,93451-15-1,4099-88-1
2,3-O-isopropylidene-D-ribofuranose

: 101155-36-6
triethylammonium salt of 1-<5-O-(2-fluorophenyl)phosphono-2,3-O-isopropylidene-α-D-ribofuranosyl>-5,6-dimethylbenzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / pyridine / CH₂Cl₂ / 0 deg C, 12 h, RT, 12 h

2: 81 percent / SnBr₂, nBuLi / tetrahydrofuran; hexane / 0 - 22 °C

With pyridine; n-butyllithium; tin(II) bromide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1246/cl.1985.1087

Reference yield:

: 53676-17-8
2-fluorophenyl phosphorochloridate

: 101155-36-6
triethylammonium salt of 1-<5-O-(2-fluorophenyl)phosphono-2,3-O-isopropylidene-α-D-ribofuranosyl>-5,6-dimethylbenzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / pyridine / CH₂Cl₂ / 0 deg C, 12 h, RT, 12 h

2: 81 percent / SnBr₂, nBuLi / tetrahydrofuran; hexane / 0 - 22 °C

With pyridine; n-butyllithium; tin(II) bromide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1246/cl.1985.1087