(R)-3-((S)-1-Benzyloxycarbonyl-2,2-dimethyl-propylcarbamoyl)-6-phenyl-hexanoic acid tert-butyl ester

Base Information

• Chemical Name: (R)-3-((S)-1-Benzyloxycarbonyl-2,2-dimethyl-propylcarbamoyl)-6-phenyl-hexanoic acid tert-butyl ester
• CAS No.: 218167-61-4
• Molecular Formula: C₃₀H₄₁NO₅
• Molecular Weight: 495.659
• Mol file: 218167-61-4.mol

Synonyms:(R)-3-((S)-1-Benzyloxycarbonyl-2,2-dimethyl-propylcarbamoyl)-6-phenyl-hexanoic acid tert-butyl ester

Chemical Property of (R)-3-((S)-1-Benzyloxycarbonyl-2,2-dimethyl-propylcarbamoyl)-6-phenyl-hexanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-((S)-1-Benzyloxycarbonyl-2,2-dimethyl-propylcarbamoyl)-6-phenyl-hexanoic acid tert-butyl ester

There total 1 articles about (R)-3-((S)-1-Benzyloxycarbonyl-2,2-dimethyl-propylcarbamoyl)-6-phenyl-hexanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-leucine benzyl ester (154092-64-5) + (2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-phenylpentanoic acid (156109-64-7) → (R)-3-((S)-1-Benzyloxycarbonyl-2,2-dimethyl-propylcarbamoyl)-6-phenyl-hexanoic acid tert-butyl ester (218167-61-4)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/S0960-894X(00)00719-8

Reference yield: 99.0%

(R)-3-((S)-1-Benzyloxycarbonyl-2,2-dimethyl-propylcarbamoyl)-6-phenyl-hexanoic acid tert-butyl ester (218167-61-4) → (R)-3-((S)-1-Carboxy-2,2-dimethyl-propylcarbamoyl)-6-phenyl-hexanoic acid tert-butyl ester (218167-60-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; water; at 20 ℃; under 2250.18 Torr;

DOI:10.1016/S0960-894X(00)00719-8

Reference yield:

(R)-3-((S)-1-Benzyloxycarbonyl-2,2-dimethyl-propylcarbamoyl)-6-phenyl-hexanoic acid tert-butyl ester (218167-61-4) → (R)-3-((S)-2,2-Dimethyl-1-phenylcarbamoyl-propylcarbamoyl)-6-phenyl-hexanoic acid (343256-67-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / H₂ / Pd/C / ethanol; H₂O / 20 °C / 2250.18 Torr

2: PyAOP; collidine / CH₂Cl₂ / 0 - 20 °C

3: HCl gas / CH₂Cl₂ / 0 - 20 °C

With 2,3,5-trimethyl-pyridine; hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane; water;

DOI:10.1016/S0960-894X(00)00719-8

upstream raw materials:

tert-leucine benzyl ester

(2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-phenylpentanoic acid

Downstream raw materials:

(R)-3-((S)-1-Carboxy-2,2-dimethyl-propylcarbamoyl)-6-phenyl-hexanoic acid tert-butyl ester

(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-phenyl-hexanoic acid

(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-phenyl-hexanoic acid tert-butyl ester

(R)-3-((S)-1-tert-Butylcarbamoyl-2,2-dimethyl-propylcarbamoyl)-6-phenyl-hexanoic acid