(R)-1-(5-chlorothiophene-2-carbonyl)-N-methyl-N-(4-(2-oxopiperidin-1-yl)phenyl)piperidine-3-carboxamide

Base Information

Chemical Name:(R)-1-(5-chlorothiophene-2-carbonyl)-N-methyl-N-(4-(2-oxopiperidin-1-yl)phenyl)piperidine-3-carboxamide
CAS No.:1394169-76-6
Molecular Formula:C₂₃H₂₆ClN₃O₃S
Molecular Weight:459.997
Hs Code.:

Synonyms:(R)-1-(5-chlorothiophene-2-carbonyl)-N-methyl-N-(4-(2-oxopiperidin-1-yl)phenyl)piperidine-3-carboxamide

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Chemical Property of (R)-1-(5-chlorothiophene-2-carbonyl)-N-methyl-N-(4-(2-oxopiperidin-1-yl)phenyl)piperidine-3-carboxamide

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Technology Process of (R)-1-(5-chlorothiophene-2-carbonyl)-N-methyl-N-(4-(2-oxopiperidin-1-yl)phenyl)piperidine-3-carboxamide

There total 5 articles about (R)-1-(5-chlorothiophene-2-carbonyl)-N-methyl-N-(4-(2-oxopiperidin-1-yl)phenyl)piperidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 498-95-3,25137-00-2,59045-82-8,60252-41-7,262853-93-0
(R)-nipecotic acid

: 1394169-76-6
(R)-1-(5-chlorothiophene-2-carbonyl)-N-methyl-N-(4-(2-oxopiperidin-1-yl)phenyl)piperidine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 5 h / 20 °C

2: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

3: 10% Pd(OH)₂ on C; hydrogen / methanol; tert-butyl alcohol / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

With dmap; 10% Pd(OH)₂ on C; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2012.06.032

Reference yield:

: 24065-33-6
5-Chlorothiophene-2-carboxylic acid

: 1394170-07-0
C₁₈H₂₅N₃O₂

: 1394169-76-6
(R)-1-(5-chlorothiophene-2-carbonyl)-N-methyl-N-(4-(2-oxopiperidin-1-yl)phenyl)piperidine-3-carboxamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.06.032

Reference yield:

: 675-20-7
piperidin-2-one

: 1394169-76-6
(R)-1-(5-chlorothiophene-2-carbonyl)-N-methyl-N-(4-(2-oxopiperidin-1-yl)phenyl)piperidine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / toluene / Inert atmosphere; Reflux

2: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

3: 10% Pd(OH)₂ on C; hydrogen / methanol; tert-butyl alcohol / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

With dmap; copper(l) iodide; 10% Pd(OH)₂ on C; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N`-dimethylethylenediamine; In methanol; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2012.06.032