(R)-benzyl 3-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate

Base Information

• Chemical Name: (R)-benzyl 3-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate
• CAS No.: 1394169-75-5
• Molecular Formula: C₂₆H₃₁N₃O₄
• Molecular Weight: 449.55

Synonyms:(R)-benzyl 3-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate

Chemical Property of (R)-benzyl 3-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of (R)-benzyl 3-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate

There total 2 articles about (R)-benzyl 3-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-nipecotic acid (498-95-3,25137-00-2,59045-82-8,60252-41-7,262853-93-0) → (R)-benzyl 3-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate (1394169-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 5 h / 20 °C

2: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.ejmech.2012.06.032

Reference yield:

piperidin-2-one (675-20-7) → (R)-benzyl 3-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate (1394169-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / toluene / Inert atmosphere; Reflux

2: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

With dmap; copper(l) iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N`-dimethylethylenediamine; In dichloromethane; toluene;

DOI:10.1016/j.ejmech.2012.06.032

Reference yield: 100.0%

(R)-benzyl 3-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate (1394169-75-5) → C18H25N3O2 (1394170-07-0)

Guidance literature:

With 10% Pd(OH)₂ on C; hydrogen; In methanol; tert-butyl alcohol; at 20 ℃;

DOI:10.1016/j.ejmech.2012.06.032

upstream raw materials:

piperidin-2-one

(R)-nipecotic acid

Downstream raw materials:

C₁₈H₂₅N₃O₂

(R)-1-(5-chlorothiophene-2-carbonyl)-N-methyl-N-(4-(2-oxopiperidin-1-yl)phenyl)piperidine-3-carboxamide

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