di-tert-butyl ((5-(aminomethyl)-2,4,6-triethyl-1,3-phenylene)bis(methylene)) dicarbamate

Base Information

• Chemical Name: di-tert-butyl ((5-(aminomethyl)-2,4,6-triethyl-1,3-phenylene)bis(methylene)) dicarbamate
• CAS No.: 549507-66-6
• Molecular Formula: C₂₅H₄₃N₃O₄
• Molecular Weight: 449.634
• Mol file: 549507-66-6.mol

Synonyms:di-tert-butyl ((5-(aminomethyl)-2,4,6-triethyl-1,3-phenylene)bis(methylene)) dicarbamate

Chemical Property of di-tert-butyl ((5-(aminomethyl)-2,4,6-triethyl-1,3-phenylene)bis(methylene)) dicarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl ((5-(aminomethyl)-2,4,6-triethyl-1,3-phenylene)bis(methylene)) dicarbamate

There total 6 articles about di-tert-butyl ((5-(aminomethyl)-2,4,6-triethyl-1,3-phenylene)bis(methylene)) dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl ((5-((((benzyloxy)carbonyl)amino)methyl)-2,4,6-triethyl-1,3-phenylene)bis(methylene)) dicarbamate (1202870-44-7) → di-tert-butyl ((5-(aminomethyl)-2,4,6-triethyl-1,3-phenylene)bis(methylene)) dicarbamate (549507-66-6)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; for 2.5h;

DOI:10.1021/acs.joc.0c01206

Reference yield: 41.0%

di-tert-butyl dicarbonate (24424-99-5) + 1,3,5-triethyl-2,4,6-tris(aminomethyl)benzene (149525-65-5) → 1-[[(1,1-dimethylethoxy)carbonyl]aminomethyl]-3,5-bis(aminomethyl)-2,4,6-triethylbenzene (340722-52-3) + di-tert-butyl ((5-(aminomethyl)-2,4,6-triethyl-1,3-phenylene)bis(methylene)) dicarbamate (549507-66-6) + [3,5-bis-(tert-butoxycarbonylamino-methyl)-2,4,6-triethyl-benzyl]-carbamic acid tert-butyl ester

Guidance literature:

In chloroform; at 20 ℃;

DOI:10.1002/ejoc.202100758

Reference yield:

1,3,5-triethylbenzene (102-25-0) → di-tert-butyl ((5-(aminomethyl)-2,4,6-triethyl-1,3-phenylene)bis(methylene)) dicarbamate (549507-66-6)

Guidance literature:

Multi-step reaction with 5 steps

1: HBr / acetic acid; acetic acid / 18 h / 130 °C

2: 9.13 g / KBr; H₂SO₄ / acetic acid; acetic acid / 10 h / 130 °C

3: 89 percent / NaN₃ / dimethylformamide; H₂O; CH₂Cl₂ / 22 h / 80 °C

4: 99 percent / PPh₃; H₂O / tetrahydrofuran / 20 °C

5: CHCl₃ / 8 h

With sodium azide; sulfuric acid; water; hydrogen bromide; triphenylphosphine; potassium bromide; In tetrahydrofuran; dichloromethane; chloroform; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1039/b008694k

upstream raw materials:

di-tert-butyl dicarbonate

1,3,5-triethyl-2,4,6-tris(aminomethyl)benzene

1,3,5-triethylbenzene

1,3,5-tris(bromomethyl)-2,4,6-triethylbenzene

Downstream raw materials:

1-[(3-(N,N-bis(6-(2,2'-bipyridyl)methyl)carbamoyl)propanoyl)aminomethyl]-3,5-bis[N-((tert-butoxy)carbonyl)aminomethyl]-2,4,6-triethylbenzene

1,3-bis[[(1,1-dimethylethoxy)carbonyl]aminomethyl]-5-(4,5-dihydro-N-(1,1-dimethylethoxy)carbonyl-imidazol-2-yl)aminomethyl-2,4,6-triethylbenzene

di-tert-butyl ((S)-benzyl 3-(5-(N-(benzyloxycarbonyl)carbamimidoylcarbamoyl)-1H-pyrrole-2-carboxamido)-1-oxopropan-2-ylcarbamate-2,4,6-triethyl-1,3-phenylene)bis(methylene)dicarbamate

1-[(3-(N,N-bis(6-(2,2'-bipyridyl-1,1'-dioxide)methyl)carbamoyl)propanoyl)aminomethyl]-3,5-bis[N-((tert-butoxy)carbonyl)aminomethyl]-2,4,6-triethylbenzene