methyl 3-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl)-3-oxopropanoate

Base Information

Chemical Name:methyl 3-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl)-3-oxopropanoate
CAS No.:1160457-34-0
Molecular Formula:C₂₁H₂₀O₇
Molecular Weight:384.386
Hs Code.:

Synonyms:methyl 3-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl)-3-oxopropanoate

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Chemical Property of methyl 3-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl)-3-oxopropanoate

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Technology Process of methyl 3-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl)-3-oxopropanoate

There total 6 articles about methyl 3-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-73-6
3,5-dihydroxyphenol

: 1160457-34-0
methyl 3-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / diethyl ether / 1 h / 0 °C / Inert atmosphere

1.2: 3 h / 112 °C / Inert atmosphere

2.1: potassium carbonate / acetone / 0.5 h / Reflux; Inert atmosphere

3.1: tetrahydrofuran / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: oxygen; copper dichloride; palladium dichloride / water; N,N-dimethyl-formamide / 4 h / 65 °C / Inert atmosphere

5.1: potassium hydride; sodium hydride / tetrahydrofuran; hexane; mineral oil / 65 °C / Inert atmosphere; Reflux

With hydrogenchloride; oxygen; potassium hydride; sodium hydride; potassium carbonate; copper dichloride; palladium dichloride; In tetrahydrofuran; diethyl ether; hexane; water; N,N-dimethyl-formamide; acetone; mineral oil; 1.1: Hoesch reaction / 5.1: Claisen condensation;
DOI:10.1021/jo202366c

Reference yield:

: 1160457-28-2
4,6-dimethoxy-2-(4-methoxyphenyl)-3-vinylbenzofuran

: 1160457-34-0
methyl 3-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: oxygen; copper dichloride; palladium dichloride / water; N,N-dimethyl-formamide / 4 h / 65 °C / Inert atmosphere

2: potassium hydride; sodium hydride / tetrahydrofuran; hexane; mineral oil / 65 °C / Inert atmosphere; Reflux

With oxygen; potassium hydride; sodium hydride; copper dichloride; palladium dichloride; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; mineral oil; 2: Claisen condensation;
DOI:10.1021/jo202366c

Reference yield:

: 33646-40-1
4-methoxymandelonitrile

: 1160457-34-0
methyl 3-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / diethyl ether / 1 h / 0 °C / Inert atmosphere

1.2: 3 h / 112 °C / Inert atmosphere

2.1: potassium carbonate / acetone / 0.5 h / Reflux; Inert atmosphere

3.1: tetrahydrofuran / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: oxygen; copper dichloride; palladium dichloride / water; N,N-dimethyl-formamide / 4 h / 65 °C / Inert atmosphere

5.1: potassium hydride; sodium hydride / tetrahydrofuran; hexane; mineral oil / 65 °C / Inert atmosphere; Reflux

With hydrogenchloride; oxygen; potassium hydride; sodium hydride; potassium carbonate; copper dichloride; palladium dichloride; In tetrahydrofuran; diethyl ether; hexane; water; N,N-dimethyl-formamide; acetone; mineral oil; 1.1: Hoesch reaction / 5.1: Claisen condensation;
DOI:10.1021/jo202366c