methyl 2-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-carbonyl)-3-phenylacrylate

Base Information

Chemical Name:methyl 2-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-carbonyl)-3-phenylacrylate
CAS No.:1160457-03-3
Molecular Formula:C₂₈H₂₄O₇
Molecular Weight:472.494
Hs Code.:

Synonyms:methyl 2-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-carbonyl)-3-phenylacrylate

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Chemical Property of methyl 2-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-carbonyl)-3-phenylacrylate

Chemical Property:

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Technology Process of methyl 2-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-carbonyl)-3-phenylacrylate

There total 8 articles about methyl 2-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-carbonyl)-3-phenylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1160457-34-0
methyl 3-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl)-3-oxopropanoate

: 100-52-7
benzaldehyde

: methyl 2-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-carbonyl)-3-phenylacrylate

: 1160457-03-3
methyl 2-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-carbonyl)-3-phenylacrylate

Guidance literature:: With piperidine; acetic acid; In benzene; at 110 ℃; optical yield given as %de;

Reference yield:

: 108-73-6
3,5-dihydroxyphenol

: methyl 2-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-carbonyl)-3-phenylacrylate

: 1160457-03-3
methyl 2-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-carbonyl)-3-phenylacrylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / diethyl ether / 1 h / 0 °C / Inert atmosphere

1.2: 3 h / 112 °C / Inert atmosphere

2.1: potassium carbonate / acetone / 0.5 h / Reflux; Inert atmosphere

3.1: tetrahydrofuran / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: oxygen; copper dichloride; palladium dichloride / water; N,N-dimethyl-formamide / 4 h / 65 °C / Inert atmosphere

5.1: potassium hydride; sodium hydride / tetrahydrofuran; hexane; mineral oil / 65 °C / Inert atmosphere; Reflux

6.1: piperidine; acetic acid / benzene / 110 °C / Inert atmosphere

With piperidine; hydrogenchloride; oxygen; potassium hydride; sodium hydride; potassium carbonate; acetic acid; copper dichloride; palladium dichloride; In tetrahydrofuran; diethyl ether; hexane; water; N,N-dimethyl-formamide; acetone; mineral oil; benzene; 1.1: Hoesch reaction / 5.1: Claisen condensation / 6.1: Knoevenagel condensation;
DOI:10.1021/jo202366c

Reference yield:

: 1160457-31-7
1-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl)methyl ketone

: methyl 2-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-carbonyl)-3-phenylacrylate

: 1160457-03-3
methyl 2-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-carbonyl)-3-phenylacrylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydride; sodium hydride / tetrahydrofuran; hexane; mineral oil / 65 °C / Inert atmosphere; Reflux

2: piperidine; acetic acid / benzene / 110 °C / Inert atmosphere

With piperidine; potassium hydride; sodium hydride; acetic acid; In tetrahydrofuran; hexane; mineral oil; benzene; 1: Claisen condensation / 2: Knoevenagel condensation;
DOI:10.1021/jo202366c