(S)-1-((2S,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propan-1-one

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Chemical Name:(S)-1-((2S,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propan-1-one
CAS No.:111964-20-6
Molecular Formula:C₂₅H₃₈F₃NO₂
Molecular Weight:441.577
Hs Code.:

Synonyms:(S)-1-((2S,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propan-1-one

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Chemical Property of (S)-1-((2S,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propan-1-one

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Technology Process of (S)-1-((2S,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propan-1-one

There total 5 articles about (S)-1-((2S,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 95587-14-7,71732-80-4
(+)-(S)-trans-2-heptyl-5-butylpyrrolidine

: 111964-20-6
(S)-1-((2S,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propan-1-one

Guidance literature:: With triethylamine; dmap; In tetrahydrofuran; dichloromethane; for 12h; Ambient temperature;
DOI:10.1016/S0040-4020(01)81697-5

Reference yield:

: 111964-18-2
(3R,5S,7aS)-5-Heptyl-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole

: 111964-20-6
(S)-1-((2S,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / 0.5 h / Ambient temperature

2: 95 percent / H₂ / 10percent Pd/C / acetic acid / 6 h / 2585.7 Torr

3: NEt₃ / DMAP / CH₂Cl₂ / 16 h / Ambient temperature

With hydrogen; triethylamine; dmap; palladium on activated charcoal; In diethyl ether; dichloromethane; acetic acid;
DOI:10.1016/S0040-4039(00)95778-2

Reference yield:

: 111964-19-3
(R)-2-((2S,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-2-phenyl-ethanol

: 111964-20-6
(S)-1-((2S,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / H₂ / 10percent Pd/C / acetic acid / 6 h / 2585.7 Torr

2: NEt₃ / DMAP / CH₂Cl₂ / 16 h / Ambient temperature

With hydrogen; triethylamine; dmap; palladium on activated charcoal; In dichloromethane; acetic acid;
DOI:10.1016/S0040-4039(00)95778-2