Phenoxy-acetic acid (4aR,5R,7R,7aR)-3-(diphenyl-phosphinoyloxy)-7-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b][1,4]dioxin-5-ylmethyl ester

Base Information

Chemical Name:Phenoxy-acetic acid (4aR,5R,7R,7aR)-3-(diphenyl-phosphinoyloxy)-7-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b][1,4]dioxin-5-ylmethyl ester
CAS No.:188404-23-1
Molecular Formula:C₃₂H₃₁N₂O₁₀P
Molecular Weight:634.579
Hs Code.:

Phenoxy-acetic acid (4aR,5R,7R,7aR)-3-(diphenyl-phosphinoyloxy)-7-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b][1,4]dioxin-5-ylmethyl ester

Synonyms:Phenoxy-acetic acid (4aR,5R,7R,7aR)-3-(diphenyl-phosphinoyloxy)-7-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b][1,4]dioxin-5-ylmethyl ester

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Chemical Property of Phenoxy-acetic acid (4aR,5R,7R,7aR)-3-(diphenyl-phosphinoyloxy)-7-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b][1,4]dioxin-5-ylmethyl ester

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Technology Process of Phenoxy-acetic acid (4aR,5R,7R,7aR)-3-(diphenyl-phosphinoyloxy)-7-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b][1,4]dioxin-5-ylmethyl ester

There total 4 articles about Phenoxy-acetic acid (4aR,5R,7R,7aR)-3-(diphenyl-phosphinoyloxy)-7-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b][1,4]dioxin-5-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 188404-22-0
Phenoxy-acetic acid (4aR,5R,7R,7aR)-3-hydroxy-7-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b][1,4]dioxin-5-ylmethyl ester

: 1499-21-4
Diphenylphosphinic chloride

: 188404-23-1
Phenoxy-acetic acid (4aR,5R,7R,7aR)-3-(diphenyl-phosphinoyloxy)-7-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b][1,4]dioxin-5-ylmethyl ester

Guidance literature:: With pyridine; dmap; In acetonitrile; at 0 ℃;
DOI:10.1016/S0960-894X(96)00607-5

Reference yield:

: 701-99-5
Phenoxyacetyl chloride

: 188404-23-1
Phenoxy-acetic acid (4aR,5R,7R,7aR)-3-(diphenyl-phosphinoyloxy)-7-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b][1,4]dioxin-5-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) pyridine, 2.) 75percent aq. HCOOH / 1.) CH₂Cl₂, room temp., 2.) 50 deg C

2: 70 percent / pyridine, DMAP / acetonitrile / 0 °C

With pyridine; dmap; formic acid; In acetonitrile;
DOI:10.1016/S0960-894X(96)00607-5

Reference yield:

: 2'-O-allyl-5-methyl uridine

: 188404-23-1
Phenoxy-acetic acid (4aR,5R,7R,7aR)-3-(diphenyl-phosphinoyloxy)-7-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b][1,4]dioxin-5-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / OsO₄, NaIO₄ / dioxane; H₂O / Ambient temperature

2: 1.) pyridine, 2.) 75percent aq. HCOOH / 1.) CH₂Cl₂, room temp., 2.) 50 deg C

3: 70 percent / pyridine, DMAP / acetonitrile / 0 °C

With pyridine; dmap; sodium periodate; osmium(VIII) oxide; formic acid; In 1,4-dioxane; water; acetonitrile;
DOI:10.1016/S0960-894X(96)00607-5