4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenesulfonamide

Base Information

Chemical Name:4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenesulfonamide
CAS No.:1345879-81-3
Molecular Formula:C₂₃H₂₀F₂N₂O₆S
Molecular Weight:490.484
Hs Code.:

Synonyms:4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenesulfonamide

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Chemical Property of 4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenesulfonamide

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Technology Process of 4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenesulfonamide

There total 11 articles about 4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99548-55-7
4-bromo-2-methyl-benzoic acid methyl ester

: 1345879-81-3
4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / 20 °C

2.1: ammonia / methanol / 0.17 h / 0 °C

2.2: 16 h / 20 °C

3.1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

4.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 80 - 90 °C / Inert atmosphere

With N-Bromosuccinimide; ammonia; potassium acetate; caesium carbonate; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; tetrachloromethane; N,N-dimethyl-formamide;

Reference yield:

: 376584-62-2
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one

: 1345882-09-8
4-((6-bromo-3-(difluoromethoxy)-2-methoxyphenoxy)methyl)benzenesulfonamide

: 1345879-81-3
4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenesulfonamide

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 3h; Inert atmosphere;

Reference yield:

: 78471-43-9
methyl 4-bromo-2-(bromomethyl)benzoate

: 1345879-81-3
4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / methanol / 0.17 h / 0 °C

1.2: 16 h / 20 °C

2.1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 80 - 90 °C / Inert atmosphere

With ammonia; potassium acetate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; N,N-dimethyl-formamide;