1-[(Z)-1-Phenylselanyl-2-(toluene-4-sulfonyl)-vinyl]-pyrrolidine

Base Information

• Chemical Name: 1-[(Z)-1-Phenylselanyl-2-(toluene-4-sulfonyl)-vinyl]-pyrrolidine
• CAS No.: 216320-37-5
• Molecular Formula: C₁₉H₂₁NO₂SSe
• Molecular Weight: 406.407
• Mol file: 216320-37-5.mol

Synonyms:1-[(Z)-1-Phenylselanyl-2-(toluene-4-sulfonyl)-vinyl]-pyrrolidine

Chemical Property of 1-[(Z)-1-Phenylselanyl-2-(toluene-4-sulfonyl)-vinyl]-pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(Z)-1-Phenylselanyl-2-(toluene-4-sulfonyl)-vinyl]-pyrrolidine

There total 3 articles about 1-[(Z)-1-Phenylselanyl-2-(toluene-4-sulfonyl)-vinyl]-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

pyrrolidine (123-75-1) + 1-phenylseleno-2-(p-toluenesulfonyl)ethyne (168064-94-6) → 1-[(Z)-1-Phenylselanyl-2-(toluene-4-sulfonyl)-vinyl]-pyrrolidine (216320-37-5) + 1-[(E)-2-Phenylselanyl-1-(toluene-4-sulfonyl)-vinyl]-pyrrolidine (168064-82-2)

Guidance literature:

In tetrahydrofuran; Ambient temperature;

DOI:10.1016/00404-0399(50)09253-

Reference yield:

Phenylselenyl chloride (5707-04-0) → 1-[(Z)-1-Phenylselanyl-2-(toluene-4-sulfonyl)-vinyl]-pyrrolidine (216320-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Et₃N / 1) diethyl ether, 5 min; 2) diethyl ether, rt, 45 min

2: 32 percent / tetrahydrofuran / 2 h / Ambient temperature

With triethylamine; In tetrahydrofuran;

DOI:10.1021/jo981224r

Reference yield:

ethynyl p-tolyl sulfone (13894-21-8) → 1-[(Z)-1-Phenylselanyl-2-(toluene-4-sulfonyl)-vinyl]-pyrrolidine (216320-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Et₃N / 1) diethyl ether, 5 min; 2) diethyl ether, rt, 45 min

2: 32 percent / tetrahydrofuran / 2 h / Ambient temperature

With triethylamine; In tetrahydrofuran;

DOI:10.1021/jo981224r

upstream raw materials:

pyrrolidine

1-phenylseleno-2-(p-toluenesulfonyl)ethyne

Phenylselenyl chloride

ethynyl p-tolyl sulfone

Downstream raw materials:

1-[2-(toluene-4-sulfonyl)-ethyl]-pyrrolidine