Technology Process of (S)-6-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,5,7,8-tetramethyl-chroman
There total 11 articles about (S)-6-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,5,7,8-tetramethyl-chroman which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: Mg; (CH2Br)2 / tetrahydrofuran / Heating
1.2: 64 percent / CuI; Me3SiCl / tetrahydrofuran; hexamethylphosphoric acid triamide / -70 °C
2.1: SnCl4 / CH2Cl2 / -70 °C
3.1: 100 percent / Ce(NH4)2(NO3)6 / acetonitrile
4.1: 96 percent / aq. HCl / methanol
5.1: 99 percent / K2CO3 / dimethylformamide
With
hydrogenchloride; ammonium cerium(IV) nitrate; tin(IV) chloride; potassium carbonate; magnesium; ethylene dibromide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1055/s-2001-14642
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: (n-Bu)4NI; aq. KOH / 20 °C
2.1: 100 percent / Br2 / CCl4 / 0 °C
3.1: Mg; (CH2Br)2 / tetrahydrofuran / Heating
3.2: 64 percent / CuI; Me3SiCl / tetrahydrofuran; hexamethylphosphoric acid triamide / -70 °C
4.1: SnCl4 / CH2Cl2 / -70 °C
5.1: 100 percent / Ce(NH4)2(NO3)6 / acetonitrile
6.1: 96 percent / aq. HCl / methanol
7.1: 99 percent / K2CO3 / dimethylformamide
With
hydrogenchloride; potassium hydroxide; ammonium cerium(IV) nitrate; bromine; tin(IV) chloride; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium; ethylene dibromide;
In
tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1055/s-2001-14642
