1-((2S,4S)-3-Benzyl-4-isopropyl-2-oxo-2λ⁵-[1,3,2]oxazaphospholidin-2-yl)-propan-2-one

Base Information

• Chemical Name: 1-((2S,4S)-3-Benzyl-4-isopropyl-2-oxo-2λ⁵-[1,3,2]oxazaphospholidin-2-yl)-propan-2-one
• CAS No.: 340146-59-0
• Molecular Formula: C₁₅H₂₂NO₃P
• Molecular Weight: 295.318

Synonyms:1-((2S,4S)-3-Benzyl-4-isopropyl-2-oxo-2λ⁵-[1,3,2]oxazaphospholidin-2-yl)-propan-2-one

Chemical Property of 1-((2S,4S)-3-Benzyl-4-isopropyl-2-oxo-2λ⁵-[1,3,2]oxazaphospholidin-2-yl)-propan-2-one

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Technology Process of 1-((2S,4S)-3-Benzyl-4-isopropyl-2-oxo-2λ⁵-[1,3,2]oxazaphospholidin-2-yl)-propan-2-one

There total 2 articles about 1-((2S,4S)-3-Benzyl-4-isopropyl-2-oxo-2λ⁵-[1,3,2]oxazaphospholidin-2-yl)-propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

ethyl acetate (141-78-6) + (2S,4S)-3-Benzyl-4-isopropyl-2-methyl-[1,3,2]oxazaphospholidine 2-oxide (340146-58-9) → 1-((2S,4S)-3-Benzyl-4-isopropyl-2-oxo-2λ5-[1,3,2]oxazaphospholidin-2-yl)-propan-2-one (340146-59-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; ethyl acetate; at -78 ℃;

DOI:10.1016/S0040-4039(01)00027-2

Reference yield:

N-benzyl-L-valinol (42807-42-1) → 1-((2S,4S)-3-Benzyl-4-isopropyl-2-oxo-2λ5-[1,3,2]oxazaphospholidin-2-yl)-propan-2-one (340146-59-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NEt₃ / CH₂Cl₂

2: 67 percent / LDA / ethyl acetate; tetrahydrofuran / -78 °C

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; ethyl acetate;

DOI:10.1016/S0040-4039(01)00027-2

Reference yield: 74.0%

6-(p-tolylaminomethylidene)-3,4-dimethoxyaniline + 1-((2S,4S)-3-Benzyl-4-isopropyl-2-oxo-2λ5-[1,3,2]oxazaphospholidin-2-yl)-propan-2-one (340146-59-0) → 3-((2S,4S)-3-Benzyl-4-isopropyl-2-oxo-2λ5-[1,3,2]oxazaphospholidin-2-yl)-6,7-dimethoxy-2-methyl-quinoline (340146-60-3)

Guidance literature:

With toluene-4-sulfonic acid; In toluene;

DOI:10.1016/S0040-4039(01)00027-2

upstream raw materials:

ethyl acetate

(2S,4S)-3-Benzyl-4-isopropyl-2-methyl-[1,3,2]oxazaphospholidine 2-oxide

N-benzyl-L-valinol

Downstream raw materials:

3-((2S,4S)-3-Benzyl-4-isopropyl-2-oxo-2λ⁵-[1,3,2]oxazaphospholidin-2-yl)-6,7-dimethoxy-2-methyl-quinoline

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