(3S,4R)-1-(tert-butoxycarbonyl)-4-(4-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid

Base Information

Chemical Name:(3S,4R)-1-(tert-butoxycarbonyl)-4-(4-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid
CAS No.:1227844-91-8
Molecular Formula:C₁₇H₂₀F₃NO₄
Molecular Weight:359.345
Hs Code.:

Synonyms:(3S,4R)-1-(tert-butoxycarbonyl)-4-(4-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid

Suppliers and Price of (3S,4R)-1-(tert-butoxycarbonyl)-4-(4-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4R)-1-(tert-butoxycarbonyl)-4-(4-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (3S,4R)-1-(tert-butoxycarbonyl)-4-(4-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid

There total 10 articles about (3S,4R)-1-(tert-butoxycarbonyl)-4-(4-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227844-92-9
C₈H₁₁N*C₁₇H₂₀F₃NO₄

: 1227844-91-8,955137-85-6
(3S,4R)-1-(tert-butoxycarbonyl)-4-(4-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid

Guidance literature:: With hydrogenchloride; In water; ethyl acetate;

Reference yield:

: C₂₇H₂₉F₃N₂O₅

: 1227844-91-8,955137-85-6
(3S,4R)-1-(tert-butoxycarbonyl)-4-(4-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1021/acs.jmedchem.8b01972

Reference yield:

: C₂₂H₂₈F₃NO₅

: 1227844-91-8,955137-85-6
(3S,4R)-1-(tert-butoxycarbonyl)-4-(4-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: lithium chloride / tetrahydrofuran / 4 h / -20 - 20 °C

2: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

With water; lithium chloride; lithium hydroxide; In tetrahydrofuran;
DOI:10.1021/acs.jmedchem.8b01972