6-nitro-N-(1-benzyl-4-piperidinyl)-1,2-benzisoxazole-3-carboxamide

Base Information

• Chemical Name: 6-nitro-N-(1-benzyl-4-piperidinyl)-1,2-benzisoxazole-3-carboxamide
• CAS No.: 186641-18-9
• Molecular Formula: C₂₀H₂₀N₄O₄
• Molecular Weight: 380.403
• Mol file: 186641-18-9.mol

Synonyms:6-nitro-N-(1-benzyl-4-piperidinyl)-1,2-benzisoxazole-3-carboxamide

Chemical Property of 6-nitro-N-(1-benzyl-4-piperidinyl)-1,2-benzisoxazole-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-nitro-N-(1-benzyl-4-piperidinyl)-1,2-benzisoxazole-3-carboxamide

There total 3 articles about 6-nitro-N-(1-benzyl-4-piperidinyl)-1,2-benzisoxazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-amino-1-benzylpiperidine (50541-93-0) + methyl 6-nitro-1,2-benzisoxazole-3-carboxylate (5453-86-1) → 6-nitro-N-(1-benzyl-4-piperidinyl)-1,2-benzisoxazole-3-carboxamide (186641-18-9)

Guidance literature:

In methanol; reflux, 5 h, rt, 12 h;

DOI:10.1016/S0223-5234(97)86174-0

Reference yield:

(2,4-dinitro-phenyl)-acetic acid (643-43-6) → 6-nitro-N-(1-benzyl-4-piperidinyl)-1,2-benzisoxazole-3-carboxamide (186641-18-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂SO₄

2: pentyl nitrite

3: 61 percent / methanol / reflux, 5 h, rt, 12 h

With n-Amyl nitrite; sulfuric acid; In methanol;

DOI:10.1016/S0223-5234(97)86174-0

Reference yield:

(2,4-dinitro-phenyl)-acetic acid methyl ester (58605-12-2) → 6-nitro-N-(1-benzyl-4-piperidinyl)-1,2-benzisoxazole-3-carboxamide (186641-18-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pentyl nitrite

2: 61 percent / methanol / reflux, 5 h, rt, 12 h

With n-Amyl nitrite; In methanol;

DOI:10.1016/S0223-5234(97)86174-0

upstream raw materials:

4-amino-1-benzylpiperidine

methyl 6-nitro-1,2-benzisoxazole-3-carboxylate

(2,4-dinitro-phenyl)-acetic acid

(2,4-dinitro-phenyl)-acetic acid methyl ester