2-(hydroxymethylene)-4-(4-(methylthio)phenyl)-1,2,3,4-tetrahydronaphthalen-1(2H)-one

Base Information

Chemical Name:2-(hydroxymethylene)-4-(4-(methylthio)phenyl)-1,2,3,4-tetrahydronaphthalen-1(2H)-one
CAS No.:1637672-65-1
Molecular Formula:C₁₈H₁₆O₂S
Molecular Weight:296.39
Hs Code.:

Synonyms:2-(hydroxymethylene)-4-(4-(methylthio)phenyl)-1,2,3,4-tetrahydronaphthalen-1(2H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(hydroxymethylene)-4-(4-(methylthio)phenyl)-1,2,3,4-tetrahydronaphthalen-1(2H)-one

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Technology Process of 2-(hydroxymethylene)-4-(4-(methylthio)phenyl)-1,2,3,4-tetrahydronaphthalen-1(2H)-one

There total 3 articles about 2-(hydroxymethylene)-4-(4-(methylthio)phenyl)-1,2,3,4-tetrahydronaphthalen-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.63%

: 1637672-61-7
4-(4-(methylthio)phenyl)-1,2,3,4-tetrahydronaphthalen-1(2H)-one

: 109-94-4
formic acid ethyl ester

: 1637672-65-1
2-(hydroxymethylene)-4-(4-(methylthio)phenyl)-1,2,3,4-tetrahydronaphthalen-1(2H)-one

Guidance literature:: formic acid ethyl ester; With sodium hydride; In ethanol; benzene; at 20 ℃; for 1h;

4-(4-(methylthio)phenyl)-1,2,3,4-tetrahydronaphthalen-1(2H)-one; In ethanol; benzene; at 20 ℃; for 1h;
DOI:10.1134/S106816201404013X

Reference yield:

: 3446-89-7
4-(Methylthio)benzaldehyde

: 1637672-65-1
2-(hydroxymethylene)-4-(4-(methylthio)phenyl)-1,2,3,4-tetrahydronaphthalen-1(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / ethanol; water / 4 h / 15 - 30 °C

2.1: sodium hydride / dimethyl sulfoxide / 0.17 h / 25 - 30 °C / Inert atmosphere

2.2: 3 h / 28 - 60 °C / Inert atmosphere

3.1: acetic anhydride; tin(IV) chloride / dichloromethane / 3 h / 25 - 28 °C / Inert atmosphere

4.1: sodium hydride / ethanol; benzene / 1 h / 20 °C

4.2: 1 h / 20 °C

With acetic anhydride; tin(IV) chloride; sodium hydride; sodium hydroxide; In ethanol; dichloromethane; water; dimethyl sulfoxide; benzene; 1.1: |Claisen-Schmidt Condensation;
DOI:10.1134/S106816201404013X

Reference yield:

: 72344-13-9
3-(4-(methylthio)phenyl)-1-phenylprop-2-en-1-one

: 1637672-65-1
2-(hydroxymethylene)-4-(4-(methylthio)phenyl)-1,2,3,4-tetrahydronaphthalen-1(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.17 h / 25 - 30 °C / Inert atmosphere

1.2: 3 h / 28 - 60 °C / Inert atmosphere

2.1: acetic anhydride; tin(IV) chloride / dichloromethane / 3 h / 25 - 28 °C / Inert atmosphere

3.1: sodium hydride / ethanol; benzene / 1 h / 20 °C

3.2: 1 h / 20 °C

With acetic anhydride; tin(IV) chloride; sodium hydride; In ethanol; dichloromethane; dimethyl sulfoxide; benzene;
DOI:10.1134/S106816201404013X