72344-13-9

Upstream product

• 98-86-2 acetophenone 
• 3446-89-7 4-(Methylthio)benzaldehyde 

Downstream Products

• 96550-90-2 3-(4-(methylthio)phenyl)-1-phenylpropan-1-one 
• 72344-14-0 (E)-3-(4-(methylsulfonyl)phenyl)-1-phenylprop-2-en-1-one 
• 72344-04-8 5-(4-methylsulfanyl-phenyl)-1,3-diphenyl-4,5-dihydro-1H-pyrazole 
• 1616765-01-5 2-(2-pyridyl)-4-(4-methylthiophenyl)-6-phenylphosphinine 
• 1616765-13-9 2-(2-pyridyl)-4-phenyl-6-(4-methylthiophenyl)phosphinine-P,N-tungsten tetracarbonyl 
• 1616764-92-1 3-(4-methylthiophenyl)-1-phenyl-5-(2-pyridyl)pentane-1,5-dione 
• 1637672-69-5 5-(4-(methylthio)phenyl)-4,5-dihydro-2H-benzo[g]indazole 
• 1637672-65-1 2-(hydroxymethylene)-4-(4-(methylthio)phenyl)-1,2,3,4-tetrahydronaphthalen-1(2H)-one 
• 1637672-61-7 4-(4-(methylthio)phenyl)-1,2,3,4-tetrahydronaphthalen-1(2H)-one 
• 1637672-57-1 (2-(4-(methylthio)phenyl)cyclopropyl)(phenyl)methanone 
• 1042441-88-2 4-phenyl-2-(4-thiomethylphenyl)-2,3-dihydro-1,5-benzothiazepine 

Relevant academic research and scientific papers

N-para-sulfonium salt substituted pyrazoline derivative, photocurable composition and preparation method

The invention relates to an N-para-sulfonium salt substituted pyrazoline derivative shown as the following formula (I) in the specification, a photocurable composition, and a preparation method of theN-para-sulfonium salt substituted pyrazoline derivative shown as the following formula (I). The N-para-sulfonium salt substituted pyrazoline derivative shown as formula (I) has good absorption at a wavelength of 350nm or above, and compared with a 5-substituted sulfonium salt, the N-para-sulfonium salt substituted pyrazoline derivative has the advantages of simpler and more convenient molecule synthesis steps and reduced cost of raw materials, and is more suitable for industrial production and application.

Sulfonium salt containing pyrazoline groups and preparation method and application thereof

The invention provides a sulfonium salt containing pyrazoline groups and a preparation method and an application thereof, wherein the general formula of the sulfonium salt is shown in the description;R and R are independently selected from hydroge

Proton-Coupled Electron Transfer: Transition-Metal-Free Selective Reduction of Chalcones and Alkynes Using Xanthate/Formic Acid

Highly chemoselective reduction of α,β-unsaturated ketones to saturated ketones and stereoselective reduction of alkynes to (E)-alkenes has been developed under a transition-metal-free condition using a xanthate/formic acid mixture through proton-coupled electron transfer (PCET). Mechanistic experiments and DFT calculations support the possibility of a concerted proton electron-transfer (CPET) pathway. This Birch-type reduction demonstrates that a small nucleophilic organic molecule can be used as a single electron-transfer (SET) reducing agent with a proper proton source.

Transition-Metal-Free Highly Chemoselective and Stereoselective Reduction with Se/DMF/H2O System

A novel metal-free reduction system, in which H2Se (or HSe-) produced in situ from Se/DMF/H2O acts as the active reducing species, has been developed. By using water as an inexpensive, safe, and environmentally friendly surrogate as the hydrogen donor, this new reduction system incorporating Se/DMF/H2O displayed high selectivity and good activity in the reduction of α,β-unsaturated ketones and alkynes. Therefore, this reduction system has great potential to be a general and practical reduction methodology in organic transformation.

Synthesis, spectral, biological activity, and crystal structure evaluation of novel pyrazoline derivatives having sulfonamide moiety

In the present study, synthesis and characterization of pyrazoline derivatives integrated with sulfonamide scaffold have been performed. The characterization of the molecules was done by elemental analysis, ultraviolet–visible, infrared, nuclear magnetic

Synthesis and pharmacological studies of new pyrazole analogues of podophyllotoxin

The pyrazole analogues of podophyllotoxin were synthesized by the chalcone route. This route attracts the attention because of its simple operating conditions and easy availability of the chemicals. Initially, benzylideneacetophenones (chalcones) were pre

Tuning the electronic effects of aromatic phosphorus heterocycles: An unprecedented phosphinine with significant P(π)-donor properties

A hitherto unprecedented electronic situation has been observed for a substituted, pyridyl-functionalized phosphinine. In contrast to previous studies, this compound shows considerable π-donor properties as the result of the rather strong +M effect of the

ALLOSTERIC PROTEIN KINASE MODULATORS

The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.

Synthesis, antioxidant evaluation, and quantitative structure-activity relationship studies of chalcones

Synthesis, antioxidant activity, and quantitative structure-activity relationship (QSAR) of 25 of chalcone derivatives is reported here. They were synthesized by Claisen-Schmidt reaction and were characterized by FTIR, NMR, and mass spectroscopy. Antioxidant activity is evaluated through four different methods namely, superoxide radical-scavenging, hydrogen peroxide scavenging, reducing power, and DPPH radical-scavenging assays. Generally, compounds with -SCH3 and -OCH3 in the para position of the A-ring and -OH in the B-ring were more active than others. In few cases some of the compounds were more active than ascorbic acid or butylated hydroxytoluene. QSAR was developed correlating the antioxidant activity with the structural features of the compounds and the predictive capability of the models was estimated using internal and external validation methods. All the predictions were within the 99% confidence level. Spatial, structural, and lipophilic properties of the compounds determine their antioxidant properties.

Novel 1,3,5-triphenyl-2-pyrazolines as anti-infective agents

Sixteen 1,3,5-triphenyl-2-pyrazolines were synthesized and their anti-infective activities (against Mycobacterium tuberculosis H37Rv, six bacterial and four fungal strains) were tested. Only compound with SO2CH3 in the para position of the A-ring was active against the tubercular strain at 100 μg/ml concentration. All compounds showed good anti infective activity against Escherichia coli and poor activity against Staphylococcus aureus. Compounds 4, 12, 13 and 14 exhibited reasonable activity against all the organisms tested (88% reduction) against four fungi studied at 2 mg/ml. All these compounds possess halogen substitutions. Compound 11 showed very high activity (>90%) against three fungi. Majority of the compounds showed more than 90% inhibition against one or two fungi. Since pyrazolines are reported to inhibit the activity of p-glycoprotein, they may prevent drug resistance developed by microorganism.