4-(4-methoxyphenyl)-5-methyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine

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Chemical Name:4-(4-methoxyphenyl)-5-methyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine
CAS No.:1573120-22-5
Molecular Formula:C₂₀H₂₀N₂O
Molecular Weight:304.392
Hs Code.:

Synonyms:4-(4-methoxyphenyl)-5-methyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine

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Chemical Property of 4-(4-methoxyphenyl)-5-methyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine

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Technology Process of 4-(4-methoxyphenyl)-5-methyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine

There total 4 articles about 4-(4-methoxyphenyl)-5-methyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1573120-21-4
4-(4-methoxyphenyl)-6H-pyrrolo[1,2-a][1,4]benzodiazepine

: 74-88-4
methyl iodide

: 1573120-22-5
4-(4-methoxyphenyl)-5-methyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine

Guidance literature:: 4-(4-methoxyphenyl)-6H-pyrrolo[1,2-a][1,4]benzodiazepine; methyl iodide; In acetone; at 150 ℃; for 0.5h; Microwave irradiation;

With sodium tetrahydroborate; In methanol; ethanol; water; at 20 ℃; for 0.166667h;
DOI:10.1007/s10593-014-1431-5

Reference yield:

: 1573120-20-3
4-methoxy-N-[2-(1H-pyrrol-1-yl)benzyl]benzamide

: 1573120-22-5
4-(4-methoxyphenyl)-5-methyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / acetonitrile / 3 h / Inert atmosphere; Reflux

2.1: acetone / 0.5 h / 150 °C / Microwave irradiation

2.2: 0.17 h / 20 °C

With trichlorophosphate; In acetone; acetonitrile;
DOI:10.1007/s10593-014-1431-5

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 1573120-22-5
4-(4-methoxyphenyl)-5-methyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 2 h / 20 °C

2.1: trichlorophosphate / acetonitrile / 3 h / Inert atmosphere; Reflux

3.1: acetone / 0.5 h / 150 °C / Microwave irradiation

3.2: 0.17 h / 20 °C

With potassium carbonate; trichlorophosphate; In acetone; acetonitrile;
DOI:10.1007/s10593-014-1431-5