1-[4-[{(1,1-dimethylethyl)dimethylsilyl}oxy]phenyl]-2,2,2-trifluoroethan-1-one

Base Information

• Chemical Name: 1-[4-[{(1,1-dimethylethyl)dimethylsilyl}oxy]phenyl]-2,2,2-trifluoroethan-1-one
• CAS No.: 760969-01-5
• Molecular Formula: C₁₄H₁₉F₃O₂Si
• Molecular Weight: 304.384
• Mol file: 760969-01-5.mol

Synonyms:1-[4-[{(1,1-dimethylethyl)dimethylsilyl}oxy]phenyl]-2,2,2-trifluoroethan-1-one

Chemical Property of 1-[4-[{(1,1-dimethylethyl)dimethylsilyl}oxy]phenyl]-2,2,2-trifluoroethan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[4-[{(1,1-dimethylethyl)dimethylsilyl}oxy]phenyl]-2,2,2-trifluoroethan-1-one

There total 3 articles about 1-[4-[{(1,1-dimethylethyl)dimethylsilyl}oxy]phenyl]-2,2,2-trifluoroethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyl trifluoroacetate, (383-63-1) + t-butyldimethylsilyl-4-bromophenol (67963-68-2) → 1-[4-[{(1,1-dimethylethyl)dimethylsilyl}oxy]phenyl]-2,2,2-trifluoroethan-1-one (760969-01-5)

Guidance literature:

t-butyldimethylsilyl-4-bromophenol; With n-butyllithium; In diethyl ether; hexane; at -80 - 0 ℃; for 1h; Inert atmosphere;

ethyl trifluoroacetate,; In diethyl ether; at -80 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c9cc08936e

Reference yield: 56.0%

N-(trifluoroacetyl)piperidine (340-07-8) + t-butyldimethylsilyl-4-bromophenol (67963-68-2) → 1-[4-[{(1,1-dimethylethyl)dimethylsilyl}oxy]phenyl]-2,2,2-trifluoroethan-1-one (760969-01-5)

Guidance literature:

With magnesium; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tetlet.2004.06.085

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 1-[4-[{(1,1-dimethylethyl)dimethylsilyl}oxy]phenyl]-2,2,2-trifluoroethan-1-one (760969-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / imidazole / dimethylformamide / 0 - 20 °C

2: 56 percent / Mg / tetrahydrofuran / 20 °C

With 1H-imidazole; magnesium; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Grignard reaction;

DOI:10.1016/j.tetlet.2004.06.085

upstream raw materials:

N-(trifluoroacetyl)piperidine

t-butyldimethylsilyl-4-bromophenol

tert-butyldimethylsilyl chloride

ethyl trifluoroacetate,