methyl 5-bromo-3-((1R,4R)-(4-((tert-butoxycarbonyl)-amino)-cyclohexyl)-(methyl)-amino)-2-methylbenzoate

Base Information

Chemical Name:methyl 5-bromo-3-((1R,4R)-(4-((tert-butoxycarbonyl)-amino)-cyclohexyl)-(methyl)-amino)-2-methylbenzoate
CAS No.:1403257-75-9
Molecular Formula:C₂₁H₃₁BrN₂O₄
Molecular Weight:455.392
Hs Code.:

Synonyms:methyl 5-bromo-3-((1R,4R)-(4-((tert-butoxycarbonyl)-amino)-cyclohexyl)-(methyl)-amino)-2-methylbenzoate

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Chemical Property of methyl 5-bromo-3-((1R,4R)-(4-((tert-butoxycarbonyl)-amino)-cyclohexyl)-(methyl)-amino)-2-methylbenzoate

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Technology Process of methyl 5-bromo-3-((1R,4R)-(4-((tert-butoxycarbonyl)-amino)-cyclohexyl)-(methyl)-amino)-2-methylbenzoate

There total 4 articles about methyl 5-bromo-3-((1R,4R)-(4-((tert-butoxycarbonyl)-amino)-cyclohexyl)-(methyl)-amino)-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.33%

: 1403258-26-3
methyl 5-bromo-3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)-amino)-2-methylbenzoate

: 74-88-4
methyl iodide

: 1403257-75-9
methyl 5-bromo-3-((1R,4R)-(4-((tert-butoxycarbonyl)-amino)-cyclohexyl)-(methyl)-amino)-2-methylbenzoate

Guidance literature:: With caesium carbonate; In acetonitrile; at 80 ℃; for 7h; Product distribution / selectivity;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1403257-75-9
methyl 5-bromo-3-((1R,4R)-(4-((tert-butoxycarbonyl)-amino)-cyclohexyl)-(methyl)-amino)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

3.1: acetic acid / methanol / 8 h / 20 °C

3.2: 0 °C

4.1: caesium carbonate / acetonitrile / 7 h / 80 °C

With iron; sodium carbonate; ammonium chloride; caesium carbonate; acetic acid; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 220514-28-3
5-bromo-2-methyl-3-nitrobenzoic acid methyl ester

: 1403257-75-9
methyl 5-bromo-3-((1R,4R)-(4-((tert-butoxycarbonyl)-amino)-cyclohexyl)-(methyl)-amino)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

2.1: acetic acid / methanol / 8 h / 20 °C

2.2: 0 °C

3.1: caesium carbonate / acetonitrile / 7 h / 80 °C

With iron; ammonium chloride; caesium carbonate; acetic acid; In methanol; ethanol; water; acetonitrile;