2-diazo-3-[5-methoxy-2-(5-methoxy-1-indanyl)phenyl]-3-oxopropionic acid ethyl ester

Base Information

Chemical Name:2-diazo-3-[5-methoxy-2-(5-methoxy-1-indanyl)phenyl]-3-oxopropionic acid ethyl ester
CAS No.:609337-92-0
Molecular Formula:C₂₂H₂₂N₂O₅
Molecular Weight:394.427
Hs Code.:

Synonyms:2-diazo-3-[5-methoxy-2-(5-methoxy-1-indanyl)phenyl]-3-oxopropionic acid ethyl ester

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Chemical Property of 2-diazo-3-[5-methoxy-2-(5-methoxy-1-indanyl)phenyl]-3-oxopropionic acid ethyl ester

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Technology Process of 2-diazo-3-[5-methoxy-2-(5-methoxy-1-indanyl)phenyl]-3-oxopropionic acid ethyl ester

There total 6 articles about 2-diazo-3-[5-methoxy-2-(5-methoxy-1-indanyl)phenyl]-3-oxopropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[5-methoxy-2-(5-methoxy-1-indanyl)phenyl]-3-oxopropionic acid ethyl ester

: 609337-92-0
2-diazo-3-[5-methoxy-2-(5-methoxy-1-indanyl)phenyl]-3-oxopropionic acid ethyl ester

Guidance literature:: With 4-acetamidobenzenesulfonyl azide; triethylamine; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1021/jm034134+

Reference yield:

: 5111-70-6
5-methoxy-1-indanone

: 609337-92-0
2-diazo-3-[5-methoxy-2-(5-methoxy-1-indanyl)phenyl]-3-oxopropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 20 °C

2.1: aq. H₂SO₄ / dioxane / 6 h / Heating

3.1: 135 g / H₂; AcOH / Pd(OH)2/C / 12 h / 20 °C / 760 Torr

4.1: (COCl)2; DMF / toluene / 4 h / 20 °C

5.1: KHMDS / tetrahydrofuran; toluene / 1 h / -78 °C

5.2: tetrahydrofuran; toluene / 1 h / -78 °C

6.1: 106 g / 4-acetoamidobenzenesulfonyl azide; Et₃N / acetonitrile / 2 h / 20 °C

With oxalyl dichloride; sulfuric acid; 4-acetamidobenzenesulfonyl azide; hydrogen; potassium hexamethylsilazane; acetic acid; triethylamine; N,N-dimethyl-formamide; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; toluene; acetonitrile;
DOI:10.1021/jm034134+

Reference yield:

: C₁₂H₁₄BrMgNO₂

: 609337-92-0
2-diazo-3-[5-methoxy-2-(5-methoxy-1-indanyl)phenyl]-3-oxopropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 20 °C

2.1: aq. H₂SO₄ / dioxane / 6 h / Heating

3.1: 135 g / H₂; AcOH / Pd(OH)2/C / 12 h / 20 °C / 760 Torr

4.1: (COCl)2; DMF / toluene / 4 h / 20 °C

5.1: KHMDS / tetrahydrofuran; toluene / 1 h / -78 °C

5.2: tetrahydrofuran; toluene / 1 h / -78 °C

6.1: 106 g / 4-acetoamidobenzenesulfonyl azide; Et₃N / acetonitrile / 2 h / 20 °C

With oxalyl dichloride; sulfuric acid; 4-acetamidobenzenesulfonyl azide; hydrogen; potassium hexamethylsilazane; acetic acid; triethylamine; N,N-dimethyl-formamide; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; toluene; acetonitrile;
DOI:10.1021/jm034134+