2-tert-butyl 1-ethyl 3-(5-fluoro-2-methoxyphenyl)-4,5,6,7-tetrahydro-2H-isoindole-1,2-dicarboxylate

Base Information

Chemical Name:2-tert-butyl 1-ethyl 3-(5-fluoro-2-methoxyphenyl)-4,5,6,7-tetrahydro-2H-isoindole-1,2-dicarboxylate
CAS No.:1269818-12-3
Molecular Formula:C₂₃H₂₈FNO₅
Molecular Weight:417.477
Hs Code.:

Synonyms:2-tert-butyl 1-ethyl 3-(5-fluoro-2-methoxyphenyl)-4,5,6,7-tetrahydro-2H-isoindole-1,2-dicarboxylate

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Chemical Property of 2-tert-butyl 1-ethyl 3-(5-fluoro-2-methoxyphenyl)-4,5,6,7-tetrahydro-2H-isoindole-1,2-dicarboxylate

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Technology Process of 2-tert-butyl 1-ethyl 3-(5-fluoro-2-methoxyphenyl)-4,5,6,7-tetrahydro-2H-isoindole-1,2-dicarboxylate

There total 4 articles about 2-tert-butyl 1-ethyl 3-(5-fluoro-2-methoxyphenyl)-4,5,6,7-tetrahydro-2H-isoindole-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1269818-09-8
2-tert-butyl 1-ethyl 3-bromo-4,5,6,7-tetrahydro-2H-isoindole-1,2-dicarboxylate

: 179897-94-0
(5-fluoro-2-methoxyphenyl)boronic acid

: 1269818-12-3
2-tert-butyl 1-ethyl 3-(5-fluoro-2-methoxyphenyl)-4,5,6,7-tetrahydro-2H-isoindole-1,2-dicarboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; water; toluene; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ja110427e

Reference yield:

: 2999-46-4
Ethyl isocyanoacetate

: 1269818-12-3
2-tert-butyl 1-ethyl 3-(5-fluoro-2-methoxyphenyl)-4,5,6,7-tetrahydro-2H-isoindole-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2: N-Bromosuccinimide / tetrahydrofuran / 0.5 h / 20 °C

3: dmap / acetonitrile / 16 h / 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; water; toluene / 16 h / 80 °C / Inert atmosphere

With dmap; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; water; toluene; acetonitrile; 4: Suzuki coupling;
DOI:10.1021/ja110427e

Reference yield:

: 2562-37-0
1-nitrocyclohexene

: 1269818-12-3
2-tert-butyl 1-ethyl 3-(5-fluoro-2-methoxyphenyl)-4,5,6,7-tetrahydro-2H-isoindole-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2: N-Bromosuccinimide / tetrahydrofuran / 0.5 h / 20 °C

3: dmap / acetonitrile / 16 h / 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; water; toluene / 16 h / 80 °C / Inert atmosphere

With dmap; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; water; toluene; acetonitrile; 4: Suzuki coupling;
DOI:10.1021/ja110427e