pyridine-2-carboxylic acid {4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide

Base Information

Chemical Name:pyridine-2-carboxylic acid {4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide
CAS No.:1276130-00-7
Molecular Formula:C₂₅H₁₇ClN₄O₂S
Molecular Weight:472.955
Hs Code.:

Synonyms:pyridine-2-carboxylic acid {4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide

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Chemical Property of pyridine-2-carboxylic acid {4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide

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Technology Process of pyridine-2-carboxylic acid {4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide

There total 4 articles about pyridine-2-carboxylic acid {4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-98-6
2-Picolinic acid

: C₁₉H₁₄ClN₃OS*(x)ClH

: 1276130-00-7
pyridine-2-carboxylic acid {4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In N,N-dimethyl-formamide; at 60 ℃;

Reference yield:

: 380430-49-9
[4-(tert-butoxycarbonylamino)phenyl]boronic acid

: 1276130-00-7
pyridine-2-carboxylic acid {4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 100 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

3: triethylamine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / N,N-dimethyl-formamide / 60 °C

With hydrogenchloride; sodium carbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1276129-46-4
6-Bromo-1-(4-chloro-benzyl)-1H-thieno[3,2-d]pyrimidin-4-one

: 1276130-00-7
pyridine-2-carboxylic acid {4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-phenyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 100 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

3: triethylamine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / N,N-dimethyl-formamide / 60 °C

With hydrogenchloride; sodium carbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;